Rajiv Gandhi University of Health Sciences
First Year M. Pharmacy Degree Examination
Time: Three Hours Max. Marks: 100 Marks
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Pharmacological Screening Methods and Clinical Evaluation
(Revised Scheme 4)
Q.P. CODE: 9350
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
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LONG ESSAY (Answer any TEN) 10 X 10 = 100 Marks
- List various methods to screen analgesic agents and discuss any one.
- Enumerate methods to induce arrhythmia. Write a note on reperfusion arrhythmia.
- Enumerate various methods to evaluate a compound for anti-diabetic activity. Explain one in vitro method and chemically induced diabetes method in rat.
- Discuss one in vivo model to screen an agent for treatment of grand mal and petit mal epilepsy.
- Discuss types of animal cell cultures and give their applications in preclinical research.
- Discuss any one process of preparation of transgenic animals and write the applications of transgenic animals in pharmacology research.
- What are biomarkers? Classify them and mention their applications.
- Explain the concept of apparent volume of distribution. What are the uses of pharmacokinetic models?
- Explain the concept and importance of pharmacovigilance in drug safety.
- Explain the process of protocol writing in clinical trial.
- Describe two preclinical models to evaluate nootropic activity.
- Explain various animal models to evaluate antiulcer agents.
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