Rajiv Gandhi University of Health Sciences
First Year M Pharm Degree Examination - August 2011
[Time: 3 Hours] [Max. Marks: 100]
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Advanced Pharmacology and Toxicology
(Revised Scheme 4)
Q.P. CODE: 9349
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
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LONG ESSAY (Answer any TEN) 10 X 10 = 100 Marks
- Explain the role of various chemical mediators in inflammation.
- Explain in vivo mutagenicity tests in rodents.
- Discuss intracellular signal transduction mediated through IP3-DAG pathway.
- Describe the adrenergic transmission. Explain the biosynthesis, metabolism and physiological role of adrenaline.
- Explain the pathophysiology and pharmacotherapy of depression. Discuss the mechanism of action of sertraline.
- Classify anti-hypertensive agents with examples. Explain the mechanism of diuretics and calcium channel blockers in treatment of hypertension.
- Write a brief description of endocrine functions of pancreas. Explain the mechanism of action of oral antidiabetic drugs.
- What is osteoporosis? Explain the pathophysiology and pharmacotherapy of post-menopausal osteoporosis.
- Discuss the pathophysiology and management of urinary tract infections.
- Classify anti HIV agents. Explain the mechanism of action of Zidovudine and discuss the pharmacotherapy of HIV infection.
- What is Schizophrenia? Write its pathophysiology and pharmacotherapy.
- Write the pharmacotherapy in Peptic ulcer and write the mechanism of each class of Anti ulcer drugs.
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