Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
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Advanced Biopharmaceutics and Pharmacokinetics -II
Q.P. CODE: 5170
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Explain in detail about in vitro and in situ methods for studying absorption of drugs.
- Define non-linear pharmacokinetics. What are the causes of non-linearity? Describe Michaelis-Menten equation.
- Enumerate different categories of in vitro-in vivo correlation regarding drug product performance.
- Explain cross over study designs of bioavailability in detail. Give a note on measurement of bioavailability.
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- Discuss properties of GI tract with respect to drug absorption.
- In details explain active transport of drug absorption.
- Discuss physico chemical properties of a drug considered in drug product design.
- Describe compendia methods of dissolution testing.
- Explain formulation factors affecting drug product performance.
- Explain in brief extra vascular compartmental modeling.
- Discuss about drug interactions linked to transporters.
- Enumerate clinical significance of bioequivalence studies.
- Give a note on pharmacokinetic and pharmacodynamic drug interactions.
- Describe pharmacokinetics and pharmacodynamics of vaccines (immunotherapy).
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