Rajiv Gandhi University of Health Sciences
Second Semester M. Pharm Examination
[Time: 3 Hours] [Max. Marks: 75]
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Clinical Pharmacokinetics and Therapeutic Drug Monitoring - III
Q.P. CODE: 5183
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three) 3 X 10 = 30 Marks
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- Explain in detail about compartmental and non-compartmental modelling.
- Explain the pharmacokinetics drug interactions with suitable examples.
- How does population pharmacokinetics differ from linear pharmacokinetics? How is the analysis of population pharmacokinetic data carried out?
- Explain why and how TDM of methotrexate is carried out?
SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
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- What is clearance, and explain about the models of hepatic clearance?
- Define loading dose and maintenance dose. Give the formula for calculating the same.
- Write a note on genetic polymorphism in drug metabolism.
- Write a note on NONMEM and how is it useful in pharmacometry.
- Discuss the considerations for drug dosing in patients with hepatic impairment.
- Explain why antipsychiatry drugs need therapeutic drug monitoring.
- Write a note on Bayesian Theory.
- Write a note on conversion from intravenous to oral therapy.
- What do you understand by hepatic extraction ratio? Discuss the significance of the same.
- What are the reasons for individualization of drug dosage regimen.
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