GRANULOMAS OF UNSUSPECTED AETIOLOGY
WEGENER'S GRANULAMATOSIS
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AETIOLOGY
- Systemic d/o of unknown etiology
- Involves URT, Lungs, kidney, skin
CLINICAL FEATURES
- Clear or blood stained nasal d/c
- Later become purulent
- Nasal findings: crusting
- Granulations
- Septal perforations
- Saddle nose
- General symptoms : anaemia, fatigue, night sweats, migratory arthralgia
- Lung involvement
- Renal failure
- Biopsy done for diagnosis
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TREATMENT
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Systemic steroids, cytotoxic drugs
Cyclophosphamide and azathioprine
T CELL LYMPHOMA
- Destructive lesion, starting on one side
- Involves upper lip, oral cavity, maxilla, orbit
- Polymorphic lymphoid tissue with angiocentric & angioinvasive features
- No vasculitis
- Rapidly destructive, no systemic involvement
- Diagnosis by biopsy
- TREATMENT: radio and chemo therapy
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SARCOIDOSIS
- Unknown aetiology
- Systemic d/o ; involvement of lungs, lymph nodes, eyes, skin
- Present with submucosal nodules involving septum or inf. Turbinate with nasal obstruction, pain & epitaxis
- X ray show diffuse pulmo. Infiltrate with hilar adenopathy
- Serum & urinary Ca elevated
- Diagnosis with biopsy
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TREATMENT
- Systemic steroids
- Steroids in form of nasal spray
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RHINOLITH
- Stone formation of nasal cavity
- Usually around nucleus of small exogenous foreign body, blood clot, inspissated depositions of Ca & Mg salts
- Grows into large, irregular mass
- Cause pressure necrosis of septum & lateral wall
- TREATMENT: removed under GA
- Most of them removed via ante. Nares
- Hard, irregular ones need late. rhinotomy
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NASAL MYIASIS (Maggots in nose)
- Maggots seen to infest nose, nasopharynx, paranasal sinuses
- Flies (genus: chrysomyia) attracted to foul smelling d/c emanating from atrophic rhinitis, syphilis, leprosy infected wounds
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CLINICAL FEATURES
- First 3-4 days maggots cause irritation, sneezing, lacrimation & headache
- Thin bloodstained d/c
- Eyelids & lips become puffy
- 3rd or 4th day maggots crawl out of nose
- Foul smell around the patient
- Cause destruction. Of nose, sinuses, soft tissue of face, palate, eyeball
- Fistula in palate or around nose
- Death occur from meningitis
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TREATMENT
- All visible maggots should be picked up with forceps
- Instillation of chloroform water & oil kills them
- Nasal douche with warm saline to remove slough, crusts, dead maggots
- Patient isolated with mosquito net
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This download link is referred from the post: MBBS Lecture Notes for all subjects (updated for 2021 syllabus) - All universities
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