Rajiv Gandhi University of Health Sciences, Karnataka
I Year B. Pharm Degree Examination — 17-Nov-2021
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Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY - I (RS4)
Q.P. CODE: 2628
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- a) Explain the factors affecting SN1 & SN2 reactions.
b) Enlight the concept of rearrangement reaction of carbocation with suitable examples - a) Define activating and deactivating groups with examples.
b) Discuss the mechanism of Nitration and sulphonation of benzene. - What happens when propene is treated with hydrogen bromide? Discuss the mechanism involved in the presence and absence of peroxide.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Discuss the Bayer's strain theory with limitations.
- Write the kinetics and mechanism of E1 reaction.
- What happens when isobutyl alcohol is treated with sulphuric acid? Discuss the mechanism.
- Discuss allyl radical as resonance hybrid with orbital pictures.
- Explain the mechanism of Benzoin condensation.
- Why carboxylic acid are acidic in nature? Write the effect of electron withdrawing groups on
- Define and classify poly nuclear hydrocarbons. Outline the Howarth’s synthesis of naphthalene.
- What is Aldol condensation? Discuss the mechanism involved.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What is Frie’s rearrangement? Write an example
- Define diazocoupling reaction with example.
- Write the Hoffmann rearrangement with example.
- Define and classify carbanion with examples
- State saytzeff’s rule.
- Write the chlorination of methane.
- Outline the generation of free radicals.
- Define metamerism with example.
- Write the structure and IUPAC name of a) Formic acid b) Neopentane
- Write the structure of a) Acetanilide b) Acetophenone
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