Download RGUHS B.Pharm 1st Year 2022 November 2628 Pharmaceutical Organic Chemistry I Rs4 Question Paper

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Rajiv Gandhi University of Health Sciences, Karnataka

I Year B. Pharm Degree Examination — 23-Nov-2022

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Time: Three Hours Max. Marks: 70 Marks

PHARMACEUTICAL ORGANIC CHEMISTRY - I (RS4)

Q.P. CODE: 2628

Your answers should be specific to the questions asked

Draw neat, labeled diagrams wherever necessary

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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Compare E1 and E2 reactions with respect to the mechanism, stereochemistry and kinetics
2. Explain Bayer’s Strain theory of cycloalkanes with limitations
3. Define and give the mechanism a) Perkin’s reaction b) Benzoin condensation

SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks

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1. Define with example - a) Electrophiles b) Nucleophiles
2. Give the rules for the nomenclature of aliphatic compounds with examples.
3. Explain Diel’s alder reaction with example
4. What are cycloalkanes? Write any three methods of preparation
5. Why conjugated dienes are more stable than non-conjugated dienes explain

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6. Explain crossed Cannizaro condensation with the mechanism
7. Write the Haworth synthesis of Naphthalene
8. Outline the mechanism of Aldol condensation

SHORT ANSWERS 10 x 2 = 20 Marks

1. What is Sandmeyer’s synthesis? Give an example

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2. Write the structure and IUPAC name of a) Acetaldehyde b) Acetone
3. Define carbanion. Write one method of formation of carbanion
4. What is a polar aprotic solvent?
5. Define Lowry Bronsted theory of acid and base with examples
6. Distinguish between functional and positional isomerism

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7. What is meant by free radical? Give one example
8. Write the structures of a) 2, 2-Dimethyl propane b) 3-Chloro pentanone
9. How is aniline converted to chlorobenzene?
10. Why aliphatic amines are more basic than aromatic amines?

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