Download ABVMU MBBS 1st Year 2023 January 2312130003 Biochemistry Paper II 2023 January Question Paper

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Marks: 100

Note: Attempt all questions. Answer Part-I and Part-II in separate answer books. All part of a question should be answered together.

PART-I

PAPER CODE: 2312130003

Q.1 Long Answer Question (7+8= 15 Marks)

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1. Describe heme biosynthesis.
2. Compare and contrast major features of porphyrias.

Q.2 Short Notes Questions (within 500 words) (3x 5=15 Marks)

1. Describe DNA repair mechanism.
2. Define and classify tumour markers. Comment on their applied aspect.

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3. Describe role of P53 in cancer biology.

Q.3 Short Answer Question (within 100 words) (5x 2 = 10 Marks)

1. IgA.
2. Bence Jones protein.
3. Fibronectin.

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4. Chargaff's rule.
5. Write two Inhibitors of transcription in prokaryotes.

Q.4 Multiple Choice Questions (10 x 1 = 10 Marks)

1. Normal pH of human blood is:
   1. 7.25 to 7.85
   2. 7.35 to 7.45

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   3. 7.45 to 7.50
   4. 6.8 to 7.2
2. Lesch Nyhan syndrome is due to deficiency of:
   1. HGPRTase
   2. PRPP synthetase

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   3. Adenosine Deaminase
   4. Xanthine Oxidase
3. Abnormal collagen structure is seen in all of the following EXCEPT:
   1. I-cell disease
   2. Osteogenesis imperfecta

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   3. Menke's disease
   4. Ehlers-Danlos syndrome
4. All are components of innate immunity except:
   1. skin
   2. B cell

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   3. Macrophages
   4. NK cells
5. The selenocysteine is modified form of:
   1. Serine
   2. Cysteine

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   3. Methionine
   4. Glycine
6. In RT-PCR test for COVID19 the metal required is:
   1. Mn
   2. Mg

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   3. Zn
   4. Cr
7. Secretory proteins are synthesised by:
   1. ribosomes on nuclear membrane
   2. ribosomes on endoplasmic reticulum

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   3. free ribosomes
   4. none
8. A silent mutation is possible due to the following characteristics of the genetic code:
   1. Universality
   2. Unambiguity

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   3. Non-overlapping
   4. Degeneracy
9. The sickle cell disease is due to:
   1. T to A substitute
   2. A to T substitute

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   3. A to U substitute
   4. U to A substitute
10. ABG test results pH 7.2; pCO2=60mm Hg;
    1. Respiratory acidosis
    2. Metabolic acidosis

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    3. Respiratory alkalosis
    4. Metabolic alkalosis

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PART-II

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Q.1 Long Answer Question (2+6+7=15 Marks)

1. What is genetic code?
2. Describe properties of genetic code.
3. Write short note on mutation on gene level.

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Q.2 Short Notes Questions (within 500 words) (3x 5= 15 Marks)

1. tRNA.
2. Metabolic role of glycine.
3. Proline is alpha-helix breaker, Justify.

Q.3 Short Answer Questions (within 100 words) (5x 2 = 10 Marks)

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1. Soret peak.
2. Van den Bergh's test.
3. Catabolic product of pyrimidine.
4. Branch chain amino acids.
5. Laboratory test for phenylketonuria.

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Q.4 Multiple Choice Questions (10 x 1 = 10 Marks)

1. Which of the following radiations are mutagenic?
   1. X-rays
   2. y-rays
   3. UV rays
   4. all the above

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2. High anion gap acidosis does not occur in:
   1. Diabetic ketoacidosis
   2. Lactic acidosis
   3. Renal failure
   4. Renal tubular acidosis

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3. The ratio of the amount of nitrogen retained in the body to the nitrogen absorbed is called:
   1. Biological value
   2. Net protein utilization
   3. Protein efficiency ratio
   4. None of the above

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4. The separation of volatile substances is carried out by:
   1. Ion exchange chromatography
   2. Thin layer chromatography
   3. Gas liquid chromatography
   4. ALL

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5. Cells which no longer divide remain in which phase of cell cycle?
   1. G0
   2. G1
   3. S phase
   4. prophase

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6. The shape of oxygen dissociation curve of Hb is:
   1. Parabola
   2. Sigmoid
   3. Hyperbola
   4. Circular

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7. Monoclonal antibodies are synthesized using:
   1. DNA fingerprinting
   2. Immunoelectrophoresis
   3. Hybridoma technology
   4. Fluorescence in situ hybridization

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8. Xeroderma pigmentosum is due to defect in:
   1. Mismatch repair
   2. Direct repair
   3. Base excision repair
   4. Nucleotide excision repair

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9. All of the following are prion diseases except:
   1. Creutzfeldt-Jakob disease
   2. Kuru
   3. Intermittent Insomnia
   4. Chronic wasting disease

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10. Amber codon is:
    1. UAA
    2. UAG
    3. UGA
    4. UGG

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