Paper II
Time Allowed: Three Hours
Maximum Marks- 100
Note: Attempt all questions in serial order. Answer Section-A and Section-B in separate answer books. All parts of a question should be answered together. Illustrate your answer with suitable diagram where required.
Figures in parenthesis indicate marks allotted to a question.
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Section-A
Q1. Write in detail the clinical picture, pathogenesis, diagnosis and management of tuberculosis (20)
Q2. Write briefly on: (4x5)
- Causes of Viral pneumonia
- Dengue virus
- Covid vaccines
- Rabies
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Q3. Multiple Choice Questions: (10x1)
- XDR tuberculosis is defined as
- Resistance to Rifampicin and Isoniazid
- MDR plus resistance to any fluroquinolones plus resistance to any injectable second line anti tubercular drug
- Resistance to all second line anti tubercular drugs
- Resistance to any fluroquinolones and resistance to all injectable second line anti tubercular drugs
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- Mutations in katG gene of Mycobacterium tuberculosis are responsible for resistance to
- Isoniazid
- Rifampicin
- Pyrazinamide
- Streptomycin
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- What would be the phenotype of cells infected with HIV-1 during primary stage of the infection?
- CD4/CXCR4
- CD8/CXCR4
- CD4/CCR5
- CD8/CCR5
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- The following viruses replicate in the nucleus
- Herpesviruses
- Poxviruses
- Picornaviruses
- Paramyxovirues
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- The following is not a "slow virus" disease
- Creutzfeldt-Jacob disease
- Subacute Sclerosing Panencephalitis (SSPE)
- Herpes Simplex Encephalitis
- Progressive multifocal leukoencephalopathy (PML)
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- Bacteriophages are readily counted by the process of:
- Immunoassay
- Plaque assays
- Tissue culture
- Electron Microscopy
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- Which of the following statement about Hepatitis C virus is FALSE?
- Is associated with hepatocellular carcinoma
- May respond to interferon therapy
- Has one stable genotype only
- May cause chronic infection
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- Which of the following statements is FALSE
- Dengue virus infection result from bites by Aedes mosquitoes
- Cases of dengue haemorrhagic fever usually result from reinfection by a different serotype of dengue virus
- Pigs act as the reservoir for dengue virus
- Dengue antibodies cross react with Japanese encephalitis virus antibodies
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- According to WHO, which of the following is a bad clinical practice in management of dengue cases?
- Assessment and follow-up of patients with non-severe dengue and careful instruction of warning signs to watch out for
- Administration of acetylsalicylic acid (aspirin) or ibuprofen
- Clinical assessment of the haemodynamic status before and after each fluid bolus
- Giving intravenous fluid volume just sufficient to maintain effective circulation during the period of plasma leakage for severe dengue
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- Which of the following viruses can cause a self-limiting acute febrile illness with rash in immune-competent children but has been associated with transient aplastic crises in persons with sickle cell disease?
- Measles
- Human Parvovirus B19
- Rubella
- Herpes simplex
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Section-B
Q1. Describe parasitic infections of immune-compromised host. Discuss in detail structure, life cycle, pathogenesis and diagnosis of any one of them. (20)
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Q2. Write short notes on: (4x5)
- Candidiasis
- Dimorphic fungi
- Mucormycosis
- Subcutaneous fungal infections
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Q3. Multiple Choice Questions: (10x1)
- In malaria, the form of plasmodia that is transmitted from mosquito to human is the
- Sporozoite
- Gametocyte
- Merozoite
- Hypnozoite
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- Trophozoites, Schizonts and gametocytes of all the malarial parasites are seen in peripheral blood smear EXCEPT
- Plasmodium vivax
- Plasmodium falciparum
- Plasmodium malariae
- Plasmodium ovale
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- Which of the following statements regarding Plasmodium falciparum is FALSE
- Causes more severe disease in pregnancy
- Is associated with recurrent relapses after initial treatment because of liver hypnozoites
- Is the only malarial parasite causing greater than 20% parasitaemia
- Infection may be associated with thrombocytopenia
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- Congenital Toxoplasmosis manifest as
- Microcephaly
- Micro-opthalmus
- Hepatosplenomegaly
- ALL of the above
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- Which is the smallest tape worm infecting man
- Taenia saginata
- Taenia solium
- Hymenolepis nana
- Diphyllobothrium latum
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- Superficial fungal infection of hair shaft is called
- Pityriasis
- Piedra
- Ring worm
- Thrush
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- Which of the following is NOT a predisposing factor for mucormycosis?
- Injection drug use
- Desferoxamine therapy
- Diabetic ketoacidosis
- Patients on isavuconazole
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- Each of the following statements concerning Candida albicans is correct EXCEPT
- C. albicans is a budding yeast that forms pseudohyphae when it invades tissue
- C. albicans causes thrush
- C. albicans is transmitted primarily by respiratory aerosol
- Impaired cell mediated immunity is an important predisposing factor to disease
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- Infection with dermatophyte is most often associated with
- Intravenous drug abuse
- Inhalation of the organism from contaminated bird feces
- Adherence of the organism to skin moist by perspiration
- Fecal-oral transmission
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- Fungal cells that reproduce by budding are seen in the infected tissues of patients with
- Candidiasis, cryptococcosis, and sporotrichosis
- Mycetoma, candidiasis and mucormycosis
- Tinea corporis, tinea unguium, and tinea versicolor
- Sporotrichosis, mycetoma and aspergillosis
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