Download PTU B.Pharma 2020 Dec 5th Sem 76786 Medicinal Chemistry Ii Theory Question Paper

Download PTU I. K. Gujral Punjab Technical University (IKGPTU) B.Pharma (Bachelor of Pharmacy) 2020 December 5th Sem 76786 Medicinal Chemistry Ii Theory Previous Question Paper

Roll No.
Total No. of Pages : 03
Total No. of Questions : 22
B.Pharma (2017 Batch) (Sem. -5)
MEDICINAL CHEMISTRY II- THEORY
Subject Code : BP-501T
M.Code : 76786
Time : 3 Hrs. Max. Marks : 75
INST RUCT IONS T O CANDIDAT ES :
1 .
SECT ION-A is COMPULSORY cons is ting of TEN questions carrying TWO marks
each.
2 .
SECT ION-B contains THREE questions carrying T EN marks e ach and s tudents
have to atte mpt any T WO questio ns.
3 .
SECT ION-C c ontains NINE questions ca rrying F IVE marks eac h and s tud ents
have to atte mpt any SEVEN que stions .
SECTION-A
Choose the correct option in the following objective type questions :
1. Enzymatic decarboxylation of histidine leads to the formation of _____
A. Histamine
B. Dopamine
C. Serotonin
D. Noradrenaline
2. _____ is a aziridine ring containing antineoplastic agent.
A. Melphalan
B. Chlorambucil
C. Busulfan
D. Thiotepa
3. Amyl nitrite is an ester of isoamyl alcohol with __
A. Nitric acid
B. Nitrous acid
C. Nitric oxide
D. Nitrous oxide
4. Site of action of carbonic anhydride inhibitor class of diuretic is_____
A. Proximal tubule
B. Loop of Henle
C. Distal Tubule
D. Collecting tubule
5. _____ is acyl-2-aminoimidazoline based selective 2 adrenoceptors agonist
A. Clonidine
B. Guanabenz
C. Guanfacine
D. L-Methyldopa
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6. _____ is an alkaloid isolated from cinchona bark and used as anti-arrhythmic drug
A. Quinidine
B. Quinine
C. Cinchonine
D. Cinchonidine
7. In 5-steroids, ring A and B are fused together with_____fashion
A. Trans
B. Cis
C. Anti
D. Syn
8. _____ is characteristic feature of progestogens
A. 4 ? 3 ? Keto
B. Aromatic ring A
C. 17?-hydroxy
D. 11--Hydroxy
9. Naturally occurring thyroid hormones possess the ______ alanine side chain
A. L
B. D
C. L&D both
D. All of these
10. Which drug belongs to 2nd generation oral hypoglycemic agent?
A. Glyburide
B. Tolbutamide
C. Acetohexamide
D. Chlorpropamide
SECTION-B
11. Classify antineoplastic agents with one structural examples of each. Give synthesis and
MOA of mercaptopurine.
12. Discuss the development of angiotensin converting enzyme inhibitors for the treatment of
hypertension. Give synthesis and MOA of methyldopa hydrochloride.
13. a) Describe detailed SAR of local anesthetics.
b) Give synthesis and MOA of procaine.
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SECTION-C
14. Give structural classification of H1-antagonist and synthesis of promethazine.
15. Write a note on calcium channel blockers used for the treatment of angina.
16. Draw structures of any three H2-antagonists and give synthesis of any one of these.
17. Describe structures of thiazide class of diuretics. Give synthesis of chlorthiazide.
18. Discuss structures of cardiac glycoside used in the treatment of congestive heart failure.
19. Draw structures of any four anti-coagulants. Give structures of warfarin.
20. Describe typical structural feature of glucocorticoids and mineralocorticoids, citing two
examples of each.
21. Give brief account on glucosidase inhibitors as anti-diabetic agents and synthesis of
tolbutamide.
22. Write short note on oral contraceptives.
NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
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