0819E373
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Fill in the blanks:
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(6)1. Inherited disorder characterized by
absence of peroxisomes in the cells
is ______
2. Coenzyme required in Transmination
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reaction ______3. Polysaccharide used as a plasma
substitute ______
4. Abnormal accumulation of
sphingomyelins in the liver, spleen
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and brain causes ______5. Purely Ketogenic amino acid ______
6. Main storage form of iron is ______
2. Choose the correct option in the
following multiple choice questions:
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(4)1. Vitamin Niacin is synthesized
from amino acid: a) Tyrosine b)
Arginine c) Tryptophan d)
Methionine
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2. Example of high energy compoundis: a) Glucose-1-Phosphate b)
Glucose-6-Phosphate c) Fructose-6-
Phosphate d) Acetyl CoA
3. Laboratory evaluation of acid-base
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imbalance involves estimation of: a)pH b) HCO3 c) pCO2 d) All
4. Porphyria inherited as Autosomal
recessive disorder is: a) Congenital
Erythropoietic Porphyria b)
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Erythropoietic Protoporphyria c)Porphyria Cutanea Tarda d)
Variegate Porphyria
3.
(15)
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A 6 month old boy was brought toPediatrician with a history of very light
colour hairs and eyes and looked much
fairer than his parents and siblings. He
was also delay in developmental
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milestones. Mother also gave a historyof seizures, frequent skin infection and
an unusual mousy odour to his skin,
breath and urine.
1. What is the probable diagnosis and
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suggest its cause.2. Why his skin and hair color is fair?
3. Which test in blood and urine is to
be performed?
4. Why there is delay in developmental
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milestones?5. What is the treatment?
4. Write short notes on (Any five):
1. Enlist the substrates of
(10)
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gluconeogenesis2. Ketosis
3. Calcitriol
4. Lesch-Nyhan Syndrome.
5. Anion-Gap
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6. Transaminases5. Explain briefly (Any three):
(15)
1. Kerbs Henseleit Cycle
2. Catabolism of Purine and its
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disorders3. Functions of Vitamin C
4. Chemiosmotic theory
Section 2
6. Define lipoproteins with examples.
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Explain the metabolism of HDLcholesterol and its role in health and
disease.
(20)
7. Explain Why (Any five):
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(10)1. Neonates are more susceptible to
develop Vitamin K deficiency.
2. Eating maize causes pellagra like
symptoms.
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3. Essential fatty acids helps inprevention of fatty liver.
4. Hyperuricemia is associated with
Von-Gierke's disease.
5. Direct bilirubin is increased in
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Obstructive jaundice.6. HbA1c is a good indicator of sugar
control in T2DM.
8. Explain briefly (Any four):
(20)
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1. Isoenzymes.2. Laboratory diagnosis of diabetes
mellitus
3. Maple syrup urine disease.
4. Antioxidant vitamins.
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5. Functions of calcium