0819E379
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Answer any one
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(10)a) Explain the formation of uric acid. What
is the normal serum uric acid level? Explain
the disease associated with its
accumulation. Suggest a way for lowering
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serum uric acid level.b) Write the steps of initiation in eukaryotic
translation with a diagram. Add a note on
post translational modification. State the
mechanism of action of following
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antibiotics in inhibition of translation.2. Answer any two (case based
scenario/applied short notes) 12 (0)
a) A 2 week old female infant had
convulsion. Her mother observed a peculiar
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mousy odour in child urine. The urineshowed a positive ferric - chloride test
indicating the presence of phenyl pyruvic
acid. (a) What is the diagnosis in this case?
(b) Which enzyme is defective in the case?
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(c) What will be the physiologicalconsequence of the disease?(d) Why it
should be detected & treated as early as
possible?
b) Biochemical basis of Lesch-Nyhan
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syndrome.c) Biochemical explanation of maple syrup
c) Biochemical explanation of maple syrup
urine disease.
3. Write short notes (answer any
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three)(18)
a) t RNA
b) Importance of dietary fibre.
c) Laboratory diagnosis of AIDS.
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d) Anti oxidant enzymes.4. Answer in 2-3 lines (give
biochemical justification) five out
of six
(10)
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a) Regulation of messenger RNA stabilityprovide a control mechanism of gene
expression.
b) Glycemic index.
c) Marcophages shows beneficial effects by
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generating free radicals.d) RNA editing mechanism is responsible
for Apo B48 synthesis in intestine.
e) Hartnup's disease give rise to pellagra
like syndrome.
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f) Vitamin K deficiency is responsible forhemorrhagic disease of new born.
Section 2
5. Answer any one
(10)
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a) Write the various forms, dietary source,deficiency disorder and daily requirement of
Vitamin A. Write briefly about the
biochemistry of vision.
b) Describe the steps of catabolism of
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tyrosine. Write the inborn errors ofmetabolism associated with this pathway.
6. Answer any two (case based
scenario/applied short notes)
(12)
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a) Sources of ammonia and its metabolism.a) Sources of ammonia and its metabolism.
b) Important compounds synthesized from
glycine.
c) Okazaki fragments.
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7. Write short notes (answer anythree)
(18)
a) G proteins
b) Beriberi
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c) Structure of collagend) Wilson's disease
8. Answer in 2-3 lines (give
biochemical justification) five out
of six
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(10)a) Proteins do not migrate in electric field
at their iso electric pH
b) Vitamin B6 deficiency in children causes
convulsion.
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c) Differential splicing generates differentprotein.
d) Folic acid deficiency causes neural tube
defect.
e) Ammonia is an excellent vehicle for
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excretion of H+ ion.f) Carbohydrate rich food induces sleep
while protein rich food causes alertness.