0819E379
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 501. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Give an account of any
TWO of the following
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(10)a) Inborn errors of Metabolism associated
with catabolism of phenylalanine and
Tyrosine. (A.292) (C.351)
b) Formation of Tetrahydrofolate and
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biochemical basis of its role in DNAsynthesis. (A. 474)
c) Polymerase chain reaction and its
application. (A. 612) (C.594)
2. Write Short notes of (any
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three)(9)
a) Recombinant DNA (A. 600) (C. 579)
b) Formation of AMP and GMP from IMP
(A. 546, 547) (C.390)
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c) Nucleosomes (A. 559) (C.79)d) Structure of t-RNA (A. 578) (C. 81)
e) Mutation (A. 591) (C.535)
3. Discuss Any TWO
(6)
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a) Biological value of proteins (A. 516) (C.512)
b) Specific Dynamic action (A. 512)
(C.505)
c) Acetyl CoA is a central metabolic
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molecule (A. 305)Section 2
4. Write Short notes on (any
two)
(10)
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a) The fate and functions of Methionine andCysteine (A. 272) (C.358)
b) Formation of peptide bonds and three
biologically important peptides (A. 45)
(C.53)
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c) The absorption and transport of iron (A.498) (C.414)
5. Write Short notes on (any
two)
(9)
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a) Biochemical functions of pyridoxalphosphate (A. 471) (C.143)
b) Biologically important nucleotides.
c) Wald's visual cycle. (A. 454) (C.129)
d) Biological function of vitamin C (A. 481)
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(C.132)e) Folate trap/cycle (A. 478) (C.156)
6. Give your comments with
justification of Any SIX
(6)
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a) Vitamin k in the activation of clottingfactors. (A. 461) (C.130)
b) Allopurinol in the treatment of Gout.
c) Methotrexate as anticancer drug.
d) HGPRTase deficiency leads to Lesch-
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Nyhan syndrome. (C.396)e) Intrinsic factor (IF) deficiency causes
pernicious anemia.
f) Proteins absorb Ultraviolet radiations.
g) Copper deficiency leads to microcytic
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anemia.h) Vitamin C leads to defective collagen
synthesis.