0819E379
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1.Write the following structured long
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question:(Any 1 out of 2)(10)
a) Describe the structure if
immunoglobulin & enumerate different
immunoglobulins with two functions of
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IgG.(5+3+2=10)
b) Describe the process of Eukaryotic
Transcription. With post translation
modification.
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(5+5=10)2.Write the following case based
scenario/Applied short notes: (Any 2 out
of 3)
(12)
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a) Read the following case history andanswer the question: A full term infant
was observed to have lack of
pigmentation, blue eyes, white hair and
confirmed as a case of albinism.
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i) Name the deficient pigment.ii) Name the enzyme responsible for the
defect.
iii) Name the amino acid from which the
pigment is synthesized.
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iv) Which is the important amino acidrelated to this inborn error?
v) What are the different types of
albinism.
vi) What special dietary advice should be
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given to the patient?b) What is Gout? Describe biochemical
defects underlying a case of Gout and its
primary and secondary causes.
c) Briefly describe the principle and
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technique of gene therapy & futureprospects.
3.Write short notes: (Any 3 out of 4) (18)
a) Biologically important peptides.
b) Types-RNA
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c) Write about Recombinant DNATechnique. Vector used & its significance.
d) What is Mutation? Explain its types
with examples.
4.Answer in 2-3 sentences only:(give
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biochemical justification, Any 5 out of 6)(10)
a) Alkaptonuria patients excrete
black coloured urine.
b) Fluoride bulb is used for glucose
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estimation.c) Telomerase inhibitors have beneficial
role in treatment.
d) Tryptophan deficiency leads to
pellagra.
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e) Antibiotic Ciprofloxacin has an effecton bacterial replication but not on human
cells.
f) Positive Nitrogen balance could be seen
in pregnant women.
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Section 25.Write the following structured long
question : (Any 1 out of 2)
(10)
a) What is Phenylketonuria. What is the
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biochemical basis of treatment? Explainthe disorder.
b) Name the vitamin. Which have a role
in night vision (Vision in dim light). Give
their biochemical roles, dietary sources,
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RDA & deficiency manifestation.6.Write short notes: (Any 2 out of 3) (12)
a) Which are the factor affecting basal
metabolic rates?
b) Vitamin B12 deficiency manifestations.
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c) Antioxidants and their action withexamples.
7.Write short notes: (Any 3 out of 4) (18)
a) Wobble's hypothesis of Genetic code.
b) Functions of calcium and its deficiency
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manifestation.c) Post transcriptional Modification.
d) Wilson's disease.
8.Answer in 2-3 sentences only: (Any 5
out of 6)
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(10)a) Every newly born child must receive
injection Vitamin K.
b) Zwitter ions have no mobility in
electrophoresis.
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c) The skin has low pigmentation due tophenylalanine.
d) Vitamin C deficient children have
bleeding gums.
e) Difference between Melanin &
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Melatonin.f) Serum Creatinine estimation for renal
disorders is more specific than estimation
of serum urea.