Date: 19-02-2024
0224E 658
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours

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Max Marks: 100
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Structured Long Question (Any

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lout of 2)
(1x10 =10)
a) Describe the different types of RNA.
Give a detail account of the fannie

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process. How it is regulated? Name the

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inhibitors of transcription.
(1+5+2+2)
b) Explain the catabolism of purines &
Write a note on Gout.
(6+4)

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2. Case based scenario/Applied short
note (Any 2 out of 3)
(2x6=12)
a) A l4 years old boy is hospitalized with
symptoms of weight loss, diarrhea,

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dermatitis and dementia.
(12)
i. Name the disease. ii. Mention
(1)
four important dietary sources. iii.

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(1)
Mention the active forms of above
deficient biomolecule. iv. Give the (4)
two biochemical reactions of above
deficient molecule.

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(2)
b) 55 year old man came to the
orthopedic OPD with complaints of
pain, redness and swelling in the left

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great toe. Investigations revealed

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serum uric acid concentration of 10
mg/dl.
i. What is the probable diagnosis ? (1)
ii. Normal range of uric acid iii.
(1)

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Describe the various types of this
disease. iv. Mention the drug that (4)
can be used to treat this and explain
its mechanism of action.
(2)

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c) A three weeks old male infant with
mental retardation and convulsions.
This infant being investigated
biochemically paper chromatography for
amino acids profile showed abnormal

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elevation of phenylalanine levels.
i. Name the enzyme, which is most
likely to be defective. ii. Name the (1)
screening test available. iii. Give
(1)

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the clinical feature of this disease. (4)
iv. What is the diet and treatment for

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this disease?:
(2)
3. Write short notes (Any 3 out of 4)

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(3x6=18)
a) Metabolic changes in
starvation.
b) Lipid peroxidation
c) Polymerase chain reaction

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d) Protein energy malnutrition
4. Answer only in 2-3 sentences (Any
5 out of 6)
(5x2=10)
a) Enlist any four features of genetic

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code.
b) Basal metabolic rate
c) Write the role of chaperons.

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d) Dietary importance of fiber
e) Give the biochemical basis of

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alkaptonuria
f) Respiratory burst
Section 2
5. Structured Long Question (Any
lout of 2)

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(1x10 =10)
a) Describe the reactions of the urea
cycle. Explain how urea cycle is linked
to the citric acid cycle. Explain the
biochemical basis of neurotoxicity in

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hyperammonaemia.
(6+2+2)
b) Describe the RDA and sources of
vitamin D. Write biochemical functions
and deficiency manifestations of vitamin

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D, How vitamin D acts as hormone.

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6. Write short notes (Any 2
(2+6+2)
out of 3)
(2x6=12)

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a) Rickets
b) Fate of glycine
c) One carbon metabolism
7. Write short notes (Any 3 out of 4)
(3x6=18)

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a) Biologically important
peptides.
b) Mechanism of action of steroid
hormone.
c) Applications of recombinant DNA

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technology
d) Storage forms of iron and factors
affecting iron absorption

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8. answers only in 2-3 sentences
(Any 5 out of 6)

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(5x2=10)
a) Enumerate the products of tyrosine
b) What is neural tube defect
c) Define isoeletric pH
d) Name collagen disorders

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e) What are G proteins ~
f) Enumerate the features of scurvy

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