0324 E644
Second Year MBBS Examination
II MBBS Pathology Paper 1
Time: 3 hours
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Max Marks: 100Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
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section.4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1. Structured long questions (Any 1 out of
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2) 1x10= 10 marks(10)
a) What are Growth Factors? Enumerate any
5 growth factors and describe their
functions?
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b) Define Necrosis? Describe the varioustypes of necrosis with examples?
2. Case based or applied Short notes (Any
2 out of 3) 2x6= 12 marks
(12)
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a) A 5-year-old child presents with anorexia,evening rise in temperature and failure to
thrive. On examination the child is
underweight for his age, Temp: 99*F, Pulse:
98 BPM, Respiratory Rate: 30/min and has
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cervical and axillary lymphadenopathy. XRay shows lung consolidation i. What is
your likely diagnosis? 2, How will you
investigate this patient further?
b) A 25 year old male patient presented to
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the OPD with flu like symptoms andintermittent abdominal pains and cramps.
On examination he has a temperature of
103* F, pulse 110 BPM and was a little
agitated and confused. Per abdomen shows
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hepatomegaly and splenomegaly. He wasadmitted but within few hours developed
acute abdomen. Per operative findings
showed an ileal perforation and ulcers in
small intestine. 1) what is your likely
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diagnosis? 2)how will you investigate thispatient further?
c) What is PAP smear? Write its
interpretation and its utility?
3. Short answer, questions (any 3 out of
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4) 3x6= 18 marks(18)
a) Define cell cycle? What are its activators
and regulators?
b) What is free radical mediated injury? How
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does it occur and what are the protectivemechanisms in our body against it?
c) Define Healing? Describe Healing by 2"
intention?
d) what is the meaning and relevance of
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Non-maleficence to a doctor? Explain withexamples?
4. Very short answer questions (5 out of
6) 5x2= 10 marks
(10)
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a) Microbial carcinogenesisb) Metaplasia
c) Klinfelter Syndrome
d) Neuroblastoma
e) Cardinal Features of Acute Inflammation
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f) InfarctionSection 2
5. Structured long questions (Any 1 out of
2) 1x10 = 10
(10)
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a) What are Chronic Myeloproliferativedisorders? Write their classification and
describe any one of them?)
b) Describe the various Mismatched Blood
transfusion reactions?
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6. Case based or Applied questions (2 outof 3) 2x6= 12
(12)
a) A 60 year old male patient presented in
the OPD with complaints of generalised
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weakness and fullness in abdomen. On
examination he had Pallor +++, per abdomen
examination showed spleen ++++. His
investigations showed Hb: 6gm/dl, WBC;
1500 cells/cumm. Platelet:57000/ cumm.
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Peripheral smear examination showedpancytopenia with many tear drop cells. a.
Which test will you order next? b. What is
your likely diagnosis?
b) What are Bleeding disorders? How will
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you investigate a patient of Bleedingdisorder?
c) What are Blood Components? Enumerate
them all and describe the preparation and
indications of use of any two?
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7. Short Answers (Any 3 of 4) 3x6= 18marks
(18)
a) Beta Thalassemia
b) ABO blood group system
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c) Classification of Hemolytic anaemiad) Differences in Red and White infarct
8. Very short Answer Questions (5 out of
6) S5x2= 10
(10)
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a) Informed consentb) Transfusion transmitted diseases
c) Causes of easinophilia
d) Reperfusion injury
e) Immune surveillance
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f) Marfan syndrome