0323 E648
Second Year MBBS Examination
II MBBS Pathology Paper 1
Time: 3 hours
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Max Marks: 100Instructions: 1. Answer to the points. 2.
Figure to the right indicates marks. 3. Use
separate answer books for each section. 4.
Draw diagrams wherever necessary. 5. Write
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legibly.Section 1
1. Structured long Question (Any 1
out of 2)
(10)
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a) Define neoplasia. Discuss classificationof tumors and write characteristic
microscopic features of tumors in detail.
(2+4+4)
b) What is amyloidosis. Write the
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types of systemic amyloidosis and discussthe morphological features of amyloidosis
of kidney.
(3+3+4)
2. Case based scenario/Applied short
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notes (Any 2 out of 3)(12)
a) 30 yrs /F presented with h/o on and off
fever, cough, chest pain, anorexia and
weakness.investigations are Hb-8.0gm%
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TLC-16000/cu.mm,DLC= slightLymphocytosis, Platelets 230000/cumm. a)
What is the likely diagnosis. b)Write its
pathogenesis and suggest other
investigations to confirm your diagnosis.
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b) 40yrs/M presented with high gradefever, myalgia and rashes all over the body.
He had past history of two units of whole
blood transfusion. His blood parameters are
Hb-10 gm%,TLC-4000/cu.mm, DLC-
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slight neutrophilia Platelets 200000/cumm,CD4+Tcelis= 300ceils/pL,Xray chest
and USG abdomen showed no
organomegaly.a) What is the likely
diagnosis b) Discuss its pathogenesis and
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complicationsc) Define shock. Describe its types and
pathophysiological stages of shock.
3. Write short notes (Any 3 out of 4)
a) Autoimmunity and enumerate
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(18)autoimmune disorders
b) Phagocytosis
c) Clinical and microscopic features of
CML
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d) Write differences between necrosis andapoptosis
4. Answer In short (any 5 out of 6)
a) Define HLA System
(10)
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b) Define SLEc) Enumerate causes of leukocytosis
d) Name Blood Group Systems
e) What is Cellular Ageing
f) Define Hyperplasia
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Section 25. Structured long Question (Any 1
out of 2)
(10)
a) Describe sideroblastic anaemia. Discuss
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its types and laboratory findings.(3+3+4)
b) Define leukemia. Describe the etiology
of leukemia and FAB classification of acute
myeioblastic leukaemias.
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(2+4+4)6. Case based scenario/Applied short
notes (Amy 2 out of 3)
(12)
a) Smooths boy presented with fever,
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paSior and irritability. USG abdomenshowed hepatosplenomegaly.Hb 5mg%,
TLC 1700cumm,DLC slight
neutrophilia.MCV,MCH and MCHC are
significantly reduced & serum bilirubin
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6mg. I)Identify the diagnosis and describethe disease.II) What other Investigations
you would advice to approach the
diagnosis.
b) What is sickle ceil anemia. Describe its
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clinical features and characteristic bloodtests for the diagnosis
c) What are clinical features of mismatched
blood transfusion? Discuss various
investigations in case of blood transfusion
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reaction.7. Write short notes (Any 3 out of 4)
a) Differences between Hodgkins
(18)
disease and Non hodgkins lymphoma
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b) Disseminated Intravascular coagulation.c) Viral oncogene
d) Cryoprecipitate
8. Answer in short (Any 5 out of 6)
a) Enumerate causes of neutropenia
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(10)b) Enumerate causes of thrombocytopenia
c) What is Hemophilia
d) Routes of metastasis
e) Causes of splenomegaly
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f) Define Howell jolly bodies