Second Year MBBS Examination
II MBBS Pathology Paper 1
Time: 3 hours
Max Marks: 100
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Instructions:1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Structured long question (any one out
of two):
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1x10=10a) Define inflammation. Describe the
cardinal features of chronic inflammation.
Add a note on granuloma.
(2+5+3)
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b) Define and enumerate types of shock.Describe the salient features of septic shock.
(2+2+6)
2. Case based scenario/Applied
short notes (Any 2 out of 3):
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2x6=12a) A 50 year old female presented in surgical
OPD with H/O painless breast lump since 3
months. On examination the lump was found
to be hard in consistency. Axillary lymph
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nodes were palpable. (i) What is the likelydiagnosis? (ii) Enumerate 2 investigations
and likely findings.
b) A 60 years old male, known case of
hypertension and IHD presented with
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breathlessness at rest, and was found to havebilateral pedal oedema. O/E JVP was raised
and RS auscultation revealed basal
crepitations. (i) What is the likely diagnosis?
(ii) What is the pathogenesis of oedema?
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Describe findings in the lung in this case.c) Systemic effects of inflammation.
3. Write short notes (any three):
3x6=18
a) Spread of malignant neoplasms
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b) Lab diagnosis of beta thalassaemiac) Causes of cell injury
d) Describe the role of doctor in the health
care team.
4. Write short answers in 2-3 sentences
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(any 5 out of 6):5x2=10
a) Enumerate the stages of phagocytosis.
b) What is metaplasia? Give 2 examples.
c) What is the fate of acute inflammatory
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response?d) Name 2 disorders with alteration in
number of X chromosomes.
e) Fate of thrombus.
f) Enumerate 4 factors which influence
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wound healing.
Section 2
5. Structured long question (any one out
of two):
1x10=10
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a) Define leukaemia. Describe the salientfeatures and lab. findings in chronic myeloid
leukaemia.
(2+4+4)
b) Define anaemia. Describe the important
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features of haemolytic anaemia. Add a noteon lab diagnosis of sickle cell anaemia.
(2+5+3)
6. Case based scenario/Applied
short notes (Any 2 out of 3):
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2x6=12a) A case of severe anaemia admitted in the
medical ward was advised blood transfusion.
A few minutes after blood transfusion was
started, patient was restless and breathless.
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O/E there was tachycardia and hypotensionwith reduced urine output. (i) What is the
likely diagnosis? (ii) What further
investigations are necessary?
b) A 15 years old boy, with H/O fall 2 days
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back reported with swelling in the leftkneejoint. Clinician suspected Hemarthrosis.
His platelet count is normal, PT-14 seconds,
APTT-55 seconds. Similar problem was
reported in his maternal uncle. (i) What is
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the likely diagnosis? (ii) How will youconfirm the diagnosis and what is the
treatment?
c) Screening of blood donor.
7. Write short notes (any three):
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3x6=18a) Role of tumour markers in lab diagnosis
of cancer.
b) Archidonic acid metabolites in
inflammation.
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c) Types of infarctd) Chemotaxis.
8. Write short answers in 2-3 sentences
(any 5 out of 6):
5x2=10
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a) Hallmarks of coagulative necrosis.b) Enumerate two antioxidants.
c) Sago spleen
d) Bronze diabetes
e) Four examples of dystrophic
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calcifications.f) Mechanism of renal oedema.
Document Outline
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