0122 E491
Second Year MBBS Examination
II MBBS Pharmacology Paper 2
Time: 3 hours
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Max Marks: 1001. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each
section.
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4. Draw diagrams wherever necessary.5. Write legibly.
Section 1
1. Answer any one of the
following
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a) Classify Anti-tuberculosis drugs. Mentionthe mechanism of action, adverse drug
reactions and uses for Rifampicin.
b) Categorize different
(4+2+2+2=10)
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Antimicrobials. Describe variousMechanisms of action for antibiotics and
antimicrobials with suitable examples.
[5+3+2=10]
2. Answer Any Two of
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the followinga) A patient of 50 years of age was
prescribed tab Metronidazole by his
physician. The recommended dose co him
was 400 mg thrice per day X 5 days. On 4th
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day in late evening the patient attended acocktail party with dinner in celebration of
his friends 50th birthday. Comment on
outcome of this interaction and state
management of this condition.
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b) A 34 year old female patient who wassuffering from urinary infection was
prescribed Ciprofloxacin by her physician
for the duration of 5 days duration. On the
3rd day after taking the morning dose around
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11.00 am, as the lady was going to heroffice, she noticed reddish colour rash and
itching on her body parts exposed to sunlight
[face, neck, forearm & hand). Comment on
the likely cause for the rash and describe
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preventive as well as curative measures toovercome the same in future.
c) A women of 44 years of age visited a
doctor's clinic with symptoms of fever,
headache and running nose. She was
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diagnosed to be suffering from allergicrhinitis and so was prescribed drugs
Erythromycin along with Terfenadine by her
doctor. Explain the consequence of this drug
interaction and the measures to prevent it.
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3. Write Short Notes on Any
Three of the following:
a) Mention the adverse drug effects and uses
for Ciprofloxacin.
b) Compare and contrast between
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Metronidazole and Mebendazole.c) State the mechanism of action and
indications for Chloroquine.
d) Describe the processes of development of
resistance to antimicrobials.
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4. Answer Any Five of thefollowing briefly in 2 to 3
sentences
a) Give examples of antimicrobials that are
unsafe in pregnancy.
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b) State the pharmacological basis of using
pyridoxine with Isonicotinic acid [INH].
c) Mention antimicrobials that are
concentrated in prostate along with its
significance.
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d) State the rationale of combiningSulfamethoxazole and Trimethoprim in a
FDC.
e) Give the line of treatment of Lepra
reaction.
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f) Mention the rationale of using Ampicillinwith Probenecid.
Section 2
5. Answer any one of the
following
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a) Classify Anti-diabetic drugs. Describe themechanism of action, adverse drug reactions
(ADRs] and Indications for Metformin.
[4+4+2+2=10]
b) Classify Anti-asthma
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drugs. Give the mechanism of action,adverse drug reactions and uses for
Salbutamol
[3+3+2+2=10]
6. Answer Any Two of the
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followinga) A patient of 40 years old suffering from
moderate gastritis was prescribed tablet
"Digene" brand containing Aluminium
hydroxide and Magnesium hydroxide. He
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felt relieved after 2 days of treatment.Comment on the rationality of drag
interaction regards the ingredient of the said
tablet.
b) A 37 year old patient presented to the
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physician the complaints of breathlessnessand wheezing. This symptoms use to also
occur and aggravate during the night time
and interrupt his sleep. He was diagnosed to
be having moderate bronchial asthma.
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Enumerate the drugs used in this patientstating their respective mechanism of action.
Also mention various dosage forms and
devices used to administer the drags for
bronchial asthma.
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c) State the contraceptive method that you asa gynaecologist would recommend a newly
married women of 25 years old. She is
perfectly healthy and is interested to plan her
family.
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7. Write Short Notes on Any
Three of the following:
a) Give the Source, mechanism of action and
and uses for Castor oil.
b) State the pharmacological basis of
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combining estrogen with progestin in anOral Contraceptive pill.
c) Define a Liniment. Give the mechanism of
action & uses for Turpentine oil liniment.
d) Mention 4 drugs with their respective
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formulation/s used in Ocular pharmacology.8. Answer Any Five of the
following briefly in 2 to 3
sentences
a) Write briefly on Tetanus toxoid.
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b) Mention the therapeutic role of
Omalizumab in bronchial asthma.
c) Differentiate between Purgatives and
Laxatives with examples.
d) Describe briefly the merits and demerits
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of Radioactive lodine.e) State the properties of Calamine lotion.
f) Give the mechanism of action for
Metoclopramide.
Document Outline
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