Date: 03-02-2024
0224 E641
Second Year MBBS Examination
II MBBS Pharmacology Paper 2
Time: 3 hours

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Max Marks: 100
Instructions:
1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each

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section.
4. Draw diagrams wherever necessary.
5. Write legibly.
Section 1
1.Answer any one

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a) Classify fluoroquinolones. Write briefly
on mechanism of action, uses and side
effects of Ciprofloxacin. Discuss the
difference between first generation & second
generation fluoroquinolones.

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(3+5+2=10)
b) Enumevate the problem that arise with the

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use of antimicrobial agents. Discuss the
mechanisms of development of drug
resistance & the measures for its prevention.

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(3+5+2=10)
2.Answer Any two of the
following:
a) A 3 year old girl from malaria endemic
region presented at the emergency

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department with history of convulsion,
altered sensorium irregular high fever of
40?C, loss of appetite, abnormal behavior
for last 2 days, On examination, BP is low
with systolic BP less than 65 mmHg. Blood

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smear examination suggests P. faliciparum
malaria. Explain the drug therapy in the
treatment of the patient. Write the
mechanism of action and adverse reaction of
any one of them.

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(2x6=12)
b) A child presented with excessive thirst,
excessive urination and vomiting. Based on
the investigations, pediatrician diagnosed it
as Fanconi syndrome. A history of

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consuming an expired antibiotic agent was
obtained from the mother. Which antibiotic

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is responsible for this syndrome. Write uses
and adverse effects of above drugs.
c) A 35 years old female visited

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(2x6=12)
medicine department with complaints of
cough, evening rise of fever, loss of appetite,
weight loss since 1 month. After complete
investigations, diagnosis of pulmonary

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Koch's was made. Mention the drug regimen
for this patient. Write down the side effects
of first line drugs. Write down the
precautions to be taken by the patient.
(2x6=12)

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3.Write Short Notes on Any
three of the following:
a) Mention the treatment of urinary tract
infection.
(3x6-18)

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b) Therapeutic uses and adverse reaction of
Ketoconazole.
(3x6-18)
c) Drug therapy for pseudomembranous
colitis.

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(3x6-18)
d) General toxicity of anticancer drugs.
(3x6-18)
4.Answer Any Five of the
following briefly:

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a) Rationale of using oral neomycin for
hepatic coma.
(2x5=10)
b) Mention why clofazimine is used for
treatment of lepra reaction.

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(2x5=10)
c) Write the pharmacological basis for use of
sodium stibogluconate in kala azar (2x5=10)
d) Explain why ifosfamide is used along
with mesna in cancer treatment.

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(2x5=10)
e) Mention the treatment of Hepatitis B
infection.
(2x5=10)
f) Drugs used in Scabies

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(2x5=10)
Section 2
5.Answer any one
a) Enumerate various hormonal
contraceptive method used for female

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contraception. Discuss briefly their
mechanism of action, advantages and
disadvantages.
(3+5+2-10)
b) Discuss hormones of anterior pituitary.

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Write briefly any five physiological function
of gonadotropin & mention any two
important side effect of each.
(3+5+2=10)

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6. Answer Any Two of the following:

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a) A 57 years old woman who is on aspirin
for her knee pain since few weeks, came with
complains of severe epigastric pain mostly at
night and between meals, burning pain in
chest and sometimes nausea. Her pain

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worsened after taking aspirin and drinking
coffee, and was relieved after taking
antacids. She was diagnosed with gastritis.
Mention at least 4 different classes of drugs
with 2 examples, which can be used to

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relieve her gastritis. Discuss the management
of H.pylori infection.
(2x6=12)
b) A 24 years old primigravidae present to a
emergency room with contraction. She is

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currently 30 weeks - pregnant. What drugs
to be advised in this situation and why. Also
mention the adverse drug reaction of the
drug used.
(2x6=12)

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c) A 37 year old patient presented to the
physician with complaints of breathlessness
and wheezing. This Symptoms use to occur
and aggravate during the night time and

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interrupt his sleep. He was diagnosed to be

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having moderate bronchial asthma.
Enumerate the drugs used in this patient
stating their respective mechanism of action.
Also mention Various dosage forms and
devices used to administer the drugs for

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bronchial asthma.
(2x6=12)
7.Write Short Notes on Any Three of
the following:-
a) Mechanism of action, uses and adverse

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reaction of Prokinetic drugs.
(3x6=18)
b) Aromatase inhibitors.
(3x6=18)
c) Mechanism of action, uses and adverse

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effects of Clomiphene citrate.
(3x6=18)
d) Treatment of Dysfunctional uterine
bleeding.
(3x6=18)

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8.Answer Any Five of the foliowing
briefly:
a) Mention drugs used for psoriasis.
b) Write short note on any two
(2x5=10)

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chelating agent.
(2x5=10)
c) Mention therapeutic uses of Vit B

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complex.
(2x5=10)

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d) Mention uses and misuses of purgatives.
e) Discuss briefly about
(2x5=10)
inhalational glucocorticoids.
(2x5=10)

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f) Explain why Bisphosphonates uses for
postmenopausal osteoporosis.
(2x5=10)

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