Download MBBS TMU 1st Year 2018 MBS103 Biochemistry I Question Paper

Max Marks: 40

Note: Attempt all questions. Draw proper diagrams to support your answer.

Part 'B'

1. Discuss the metabolism of Phenylalanine in detail. Enumerate the synthesis of different products obtained from Phenylalanine/Tyrosine. (10)

--- Content provided by‍ FirstRanker.com ---

2. Explain the causes, clinical manifestations and laboratory diagnosis of the following: (5+5)

   1. Type 2 Diabetes Mellitus
   2. Sickle-cell anemia

3. Write in detail: (5+5)

   --- Content provided by‍ FirstRanker.com ---

   1. Lipotropic Factors
   2. Gout

4. Describe the following: (5+5)

   1. Metabolic changes during starvation

   --- Content provided by‌ FirstRanker.com ---

   2. Factors affecting enzyme action

Roll No.

MBBS I (First) Professional Examination 2017-18

Student's Signature

--- Content provided by⁠ FirstRanker.com ---

Course Code: MBS103

Biochemistry - I

Part 'A'

Time: 20 Minutes

Student's Name

--- Content provided by‍ FirstRanker.com ---

Invigilator's Signature

Paper ID: 0322208

Max Marks: 10

Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.

2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed.

--- Content provided by‌ FirstRanker.com ---

3. For answering please use Ball- pen only.

1. Which of the following is an epimeric pair:

   1. Glucose & maltose
   2. Glucose & Fructose
   3. Glucose & mannose

   --- Content provided by‌ FirstRanker.com ---

   4. Glucose & ribose

2. G-proteins act as:

   1. Hormone carriers
   2. Hormone receptors

   --- Content provided by⁠ FirstRanker.com ---

   3. Signal transducers
   4. Second messengers

3. Allopurinol is a competitive inhibitor of

   1. Dihydrofolate reductase

   --- Content provided by⁠ FirstRanker.com ---

   2. Xanthine oxidase
   3. Carbonic anhydrase
   4. Acetylcholinesterase

4. Cyanide inhibits phosphorylation at:

   --- Content provided by⁠ FirstRanker.com ---

   1. Site I
   2. Site II
   3. Site III
   4. Site IV

--- Content provided by‌ FirstRanker.com ---

5. Factty liver is caused due to accumulation of:

   1. Fatty acids
   2. Cholesterol
   3. Phospholipids
   4. Triacylglycerol

   --- Content provided by‍ FirstRanker.com ---

6. Aspirin and indomethacin inhibit:

   1. Phospholipase A₁
   2. Phospholipase A2
   3. Cyclo-oxygenase

   --- Content provided by‍ FirstRanker.com ---

   4. Lipo-oxygenase

7. Primary structure of a protein is broken by:

   1. Heat
   2. Ammonium sulphate

   --- Content provided by⁠ FirstRanker.com ---

   3. Pepsin
   4. All of the above

8. Which of the following nitrogenous base is absent from DNA:

   1. Uracil

   --- Content provided by‍ FirstRanker.com ---

   2. Thymine
   3. Adenine
   4. Guanine

9. Following myocardial infarction, the last serum enzyme to return to normal is:

   --- Content provided by FirstRanker.com ---

   1. Creatine kinase
   2. Aspartate transaminase
   3. Alanine transaminase
   4. Lactate dehydrogenase

--- Content provided by FirstRanker.com ---

10. Glycine is required for the formation of all of the following except:

    1. Creatine
    2. Porphyrins
    3. Pyrimidines
    4. Glutathione

    --- Content provided by‍ FirstRanker.com ---

11. Lipogenesis is decreased in all the following except:

    P.T.O.

    1. Restricted caloric intake
    2. High fat intake

    --- Content provided by⁠ FirstRanker.com ---

    3. Deficiency of insulin
    4. High carbohydrate intake

12. Free glycerol cannot be used for triglyceride synthesis in:

    1. Liver

    --- Content provided by​ FirstRanker.com ---

    2. Kidney
    3. Intestine
    4. Adipose tissue

13. Hypocholesterolemia can occur in:

    --- Content provided by​ FirstRanker.com ---

    1. Hyperthyroidism
    2. Nephrotic syndrome
    3. Obstructive jaundice
    4. Diabetes Mellitus

--- Content provided by‍ FirstRanker.com ---

14. Congenital absence of ornithine transcarbamoylase causes:

    1. Hyperammonemia type I
    2. Hyperammonemia type II
    3. Hyperornithinemia
    4. Citrullinemia

    --- Content provided by‌ FirstRanker.com ---

15. The nitrogen atoms of pyrimidine nucleus:

    1. Glutamate
    2. Glutamine
    3. Glutamate and Aspartate

    --- Content provided by‌ FirstRanker.com ---

    4. Glutamine and Aspartate

16. Kernicterus can occur in:

    1. Retention hyperbilirubinemia
    2. Regurgitation hyperbilirubinemia

    --- Content provided by‌ FirstRanker.com ---

    3. Both of the above
    4. None of the above

17. Rate limiting step fo glycolysis is catalyzed by :

    1. Glucokinase

    --- Content provided by FirstRanker.com ---

    2. Pyruvate kinase
    3. Phosphofructokinase-I
    4. Phosphohexose isomerase

18. A coenzyme present in muscle phosphorylase is:

    --- Content provided by‌ FirstRanker.com ---

    1. NAD
    2. Pyridoxal phosphate
    3. Thiamin pyrophosphate
    4. Coenzyme A

--- Content provided by‌ FirstRanker.com ---

19. Urinary excretion of homogentisic acid is increased in:

    1. Tyrosinemia
    2. Alkaptonuria
    3. Phenylketonuria
    4. Homocystinuria

    --- Content provided by‍ FirstRanker.com ---

20. Ciprofloxacin inhibits the synthesis of:

    1. DNA in prokaryotes
    2. DNA in prokaryotes and eukaryotes
    3. RNA in prokaryotes

    --- Content provided by​ FirstRanker.com ---

    4. RNA in prokaryotes and eukaryotes

Visit FirstRanker.com for more question papers.