Download MBBS (Bachelor of Medicine, Bachelor of Surgery) TMU (Teerthanker Mahaveer University) Second Year (2nd Year) 2020 MBS201 Pathology I Previous Question Paper
MBBS II (Second) Professional Examination 2019-20
Course Code: MBS201
Paper ID: 03219201
Pathology-I
Time: 2 Hours 40 Minutes
Max Marks: 30
Note: Attempt all questions. Draw proper diagrams to support
your answer.
Part `B'
1.
A 4-year old male child presents with features of growth
retardation, irritability and anorexia. Mother states that the child
was normal at birth. On examination there is marked pallor,
icterus, hepatosplenomegaly with sternal tenderness but no
lymphadenopathy. The nasal bridge is depressed along with
malar prominence. Routine blood examination reveals Hb-4.8gm
%, TLC-4000 cells/cumm, platelets- 1.5 lakh/cumm, DLC-
N60,L35,E03,M02,B0, S. Bil: 3.8mg/dl, Conjugated Bil: 0.7mg/dl,
Unconj. Bil: 3.1 mg/dl. Peripheral blood smear shows
RBC'swith anisopoikilocytosis with presence of target cells and
polychromasia and nRBCs. (1+3+3)
a)
What is your provisional diagnosis?
b)
Write the differential diagnosis based on the peripheral blood
smear findings.
c)
How will you approach to confirm the diagnosis?
2.
Define neoplasia. Discuss the modes and mechanism of spread
of tumor. Discuss the grading and staging of tumors. (1+3+3)
3.
Write short notes on: (2x4=8)
a)
Vascular changes in acute inflammation
b)
Morphological subtypes of Hodgkin's lymphoma
c)
Edward syndrome
d)
Pathogenesis of AIDS
4.
Discuss in brief: (2x4=8)
a)
Difference between necrosis and apoptosis
b)
Pathogenesis of autoimmunity
c)
Difference between red and white infarct
d)
Plasma derived chemical mediators
MBBS II (Second) Professional Examination 2019-20
Roll No.
Student's Name
Student's Signature
Invigilator's Signature
Course Code: MBS201
Paper ID: 03219201
Pathology-I
Part `A'
Time: 20 Minutes
Max Marks: 10
Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes.
2. Please tick () correct one only. Cutting, overwriting or any other marking are not allowed.
3. For answering please use Ball- pen only.
positivity of most of the tumor cells for
Q.1
A peripheral smear with increased neutrophils,
cytokeratin. The most probable diagnosis of the
basophils, eosinophils, and platelets is highly
tumor is:
suggestive of:
a)
Sarcoma
a)
Acute myeloid leukemia
b)
Lymphoma
b)
Acute lymphoblastic leukemia
c)
Carcinoma
c)
Chronic myelogenous leukemia
d)
Malignant Melanoma
d)
Myelodysplastic syndrome
Q.10
A 3-year-old boy is brought to the clinic because
Q.2
True about Apoptosis are all except:
of fever and "fussiness," and he is diagnosed as
a) Inflammation is present
having acute otitis media. In this acute
b) Chromosomal breakage
inflammatory reaction, which of the following
c) Clumping of chromatin
cells would have reached the site of inflammation
d) Cell shrinkage
first:
a)
Basophils
Q.3
Arthus reaction is what type of hypersensitivity
b)
Lymphocytes
reaction:
c)
Monocytes?macrophages
a)
Localized immune complex
d)
Neutrophils
b)
IgE mediated reaction
c)
Compliment mediated
P.T.O.
d)
Ab mediated
Q.11
Most common cause of Down's syndrome is:
a)
Translocation
Q.4.
Auer rods are seen in:
b)
Mosaicism
a)
AML
b)
CML.
c)
Paternal nondisjunction
c)
CLL
d)
ALL
d)
Maternal nondisjunction
Q.5
Oxygen dependent killing is done through:
Q.12
A 20-year-old man is found to have hemolytic
a)
NADPH oxidase
anemia with jaundice and splenomegaly. A
b)
Super oxide dismutase
younger brother is found to be similarly affected,
c)
Catalase
and his mother had a history of splenectomy.
d)
Glutathione peroxidase
Which of the following abnormality is expected in
Q.6
A 45-year-old woman has a lung biopsy because
this patient:
of a 1.0 cm lesion seen on a chest x-ray.
a)
Increased haptoglobin
Histologic examination reveals epithelioid
b)
Unconjugated hyperbilirubinemia
macrophages and lymphocytes around a focus of
c)
Marrow erythroid hypoplasia
caseous necrosis. What is the best explanation for
d)
Decreased reticulocytes
this form of necrosis:
Q.13
A 60-year-old man presents with a 3-week history
a)
Cell-mediated hypersensitivity
of lymph node enlargement in his neck and
b)
Complement fixation
axillae. A CBC reveals mild anemia, with a
c)
Local histamine release
leukocytosis of 60,000/microlitre. The peripheral
d)
PMNs releasing degradative enzymes
blood smear shows 80% of WBCs to be of small
lymphocytes, with smudge cells. Examination of
Q.7
Which of the following events in acute
a bone marrow biopsy shows nodular and
inflammation occurs first:
interstitial infiltrates of lymphocytes, which
a)
Chemotaxis
b)
Emigration
demonstrate clonal rearrangement of the IgG
c)
Hemostasis
d)
Margination
light-chain gene. Which of the following is the
Q.8
An exaggerated immune response which is
appropriate diagnosis:
harmful to the host is termed a hypersensitivity
a)
Chronic myelogenous leukemia with
reaction. Different individuals are sensitive to
lymphoid blast crisis
different antigens. First contact with the antigen
b)
Chronic lymphocytic leukemia
usually does not elicit a hypersensitivity reaction,
c)
Acute lymphoblastic lymphoma
but only 'sensitizes' the individual. Subsequent
d)
Multiple myeloma
exposure elicits the allergic response. In case of
Q.14
A 10-year old girl is brought to the emergency
type I hypersensitivity the reactions are mediated
room complaining of cough with hemoptysis and
by which of the following:
chest pain. She has a history of migration from
a)
Activated T lymphocytes on vessel walls
Sudan to USA 1 year back. Her chest X-ray
b)
Antigen-antibody complexes
shows consolidation of the lungs suggestive of
c)
Complement pathway
lobar pneumonia. Sputum examination shows
d)
IgE on basophils and mast cells
gram positive diplococci. Physical examination
Q.9
An undifferentiated malignant tumor on
reveals jaundice and pallor. Her parents state that
immunohistochemical stain shows cytoplasmic
she has been anemic since birth. A CBC shows
normocytic anemia with marked poikilocytosis. A
d)
Glucose-6-phosphate dehydrogenase
peripheral blood smear sickle shaped cells. Her
deficiency
hematological condition is best explained by
Q.19
A 60-year-old man is referred to a haematologist
which of the following pathological changes:
after complaining of back pain and tiredness as
a)
Deficiency in heme synthesis
well as recent onset low mood. Urine tests reveal
b)
Deficiency in globin synthesis
the presence of Bence?Jones proteins. An X-ray
c)
Defect in spectrin gene
of the patient's spine shows the presence of lytic
d)
Structurally abnormal type of
lesions. What is the most likely diagnosis in this
hemoglobin
patient:
Q.15
A 30- year old male is planned to undergo renal
a)
Multiple myeloma
transplant. The donor kidney is being provided by
b)
Essential thrombocythaemia
his homozygous twin brother. They ask the
c)
Myelofibrosis
physician about the chances of graft rejection.
d)
Chronic myelo-monocytic leukaemia
The physician replies that the grafts between
Q.20
In anaemia of chronic disorders, serum ferritin is:
genetically identical individuals (i.e., identical
a)
Normal
twins) are:
b)
Low
a)
Acute rejection as a result of major
c)
Increased
histocompatibility antigens
d)
Absent
b)
Subject to hyperacute rejection
c)
Not rejected
d)
Not rejected if a kidney is grafted, but
skin grafts are rejected
Q.16
A 45-year old male visits a dental clinic with
complains of poor oral hygiene. The dentist
observes a blue-black line on the gums along the
junction of teeth and gingiva. On further eliciting,
the patient admits that he had been working in a
metal industry for the past 15 years. On the basis
of these findings, chronic exposure to which of
the following metal is responsible for this clinical
presentation:
a)
Lead poisoning
b)
Beryllium poisoning
c)
Chromium poisoning
d)
Mercury poisoning
Q.17
A 59-year-old man presents with increasing
fatigue, swelling, and bone pain. Laboratory
evaluation finds increased serum protein and
calcium along with markedly increased amounts
of protein in his urine. Subsequently he develops
signs of progressive renal failure. Microscopic
examination of a renal biopsy reveals deposits of
eosinophilic, Congo red?positive material in the
glomeruli. When viewed under polarized light,
this material displays an apple-green
birefringence. What is the most likely
composition of this material:
a)
Amyloid AL type (light chains)
b)
Procalcitonin
c)
Beta-2-protein
d)
Beta-2-microglobulin
Q.18
An 18-year-old man presents to accident and
emergency after eating a meal containing Fava
beans. He is evidently jaundiced and has signs
suggestive of anaemia. The patient's blood film
reveals the presence of Heinz bodies:
a)
Hereditary sherocytosis
b)
Sickle cell anaemia
c)
Beta-Thalassaemia
This post was last modified on 17 February 2022