2019 Scheme
Q.P. Code: 115001 Reg. no.: ........................
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First Professional MBBS Degree Supplementary (SAY) Examinations
May 2022
Biochemistry - Paper I
Time: 3 Hours Total Marks: 100
- Answer all questions to the point neatly and legibly. Do not leave any blank pages between answers
- Indicate the question number correctly for the answer in the margin space
- Answer all parts of a single question together. Leave sufficient space between answers
- Draw table/diagrams/flow charts wherever necessary
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Long Essays (2x15=30)
- A 45-year-old man complaints of increased appetite, thirst, and frequent micturition. His random blood sugar is 346 mg/dl
- What is the diagnosis. What are the diagnostic criteria
- Discuss the relevant investigations that can be done for further monitoring of the patient
- How is blood glucose regulated
- What is the renal threshold for Glucose (3+4+5+3)
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- Define Beta oxidation. Enumerate the steps and add a note on its regulation. Explain the energetics for palmitic acid (2+8+1+4)
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Short essays (5x8=40)
- Enumerate the steps of TCA cycle. Add a note on malate shuttle (6+2)
- Describe the salient features of any two types of enzyme inhibition with suitable examples (2+2+2+2)
- Define nitrogen balance. Add a note on the clinical conditions altering nitrogen balance (2+6)
- Discuss the catabolism of heme. Describe the causes and laboratory finding in obstructive jaundice (5+3)
- What are the sources of vitamin A. Enumerate the biochemical role and deficiency manifestations of vitamin A (2+4+2)
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Short answers (5x4=20)
- Define Peptide bonds. Enumerate two biochemically important peptides and their significance. (2+2)
- Substrate level phosphorylation
- Golgi complex
- Discuss the formation of melanin and add a note on albinism
- Describe the synthesis of any two compounds of biomedical importance synthesized from glycine
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Give Precise Answers (10x1=10)
- Why is sucrose a non reducing sugar
- Enzyme defect in Alkaptonuria
- Name two cardiac markers
- Name two prostaglandins and mention their importance
- Enzyme defect in Von-Gierke's disease
- Give the normal reference range for Serum triglyceride • Serum creatinine
- Marker enzyme for mitochondria
- Name two compounds formed from Tryptophan
- Name the enzyme activity to assess the deficiency of vitamin B1
- Name the rate limiting enzyme of heme synthesis.
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