Download RGUHS MBBS 1st Year 1022 RGUHS MBBS Physiology Paper I RS4 2023 April Question Paper

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QP CODE: 1022

Rajiv Gandhi University of Health Sciences, Karnataka

MBBS Phase- I(CBME) Degree Examination-29-Apr-2023

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Time: Three Hours Max. Marks: 100Marks

PHYSIOLOGY- PAPER-I(RS-4)

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Q.P. CODE: 1022

(QPcontains two pages)

Your answers shouldbespecific to the questions asked

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Draw neat, labeled diagrams wherever necessary

LONG ESSAYS 2x10=20Marks

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1. Define cardiac output. Explain in detail the factorsregulatingcardiacoutput. Add a note Fick' sprinciple


2. Enumerate different types of chemo receptors. Explain their role in chemical regulation of respiration. Add a note
   on breath holding

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SHORTESSAYS 8x5=40 Marks

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1. Explain the intrinsicmechanism of blood clotting


2. Discussthecharacteristic features of coronary circulation


3. Explain the counter current multiplier system in kidney

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4. Discuss themechanism of cell mediated immunity


5. A male aged 55 years was brought to emergency department with history of retro sternal pain since morning, pain
   in epigastrium radiating to left shoulder, profuse sweating. He is a known diabetic and hypertensive on irregular
   

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   treatment
   
   a) Whatistheprobable diagnosis?
   
   b) What are the expected ECG changes in this condition?
   

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   c) Whyisthesubendocardium more prone to Ischaemia?


6. With a neat labelled diagram, explain the different lung volumes and capacities



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7. Discussthefunctions of exocrine pancreaticjuice and its regulation


8. Explain the micturition reflex and its higher control

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SHORT ANSWERS 10x3=30 Marks

1. What is ejection fraction? Mention its clinical significance



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2. Explain the significance of Timed Vital Capacity


3. Explain the physiological basis of anaemia in kidney disease


4. List the functions of salim

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5. Explain the genesis of resting membranepotential


6. Explain type l hypersensitivity reaction



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7. Explain the physiological basis of lactose intolerance


8. Enumerate the functions of lymph


9. What is respiratory acidosis? Mention one condition causing it

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10. Explain the pathophysiology of pepticulcer

Multiple Choice Questions 10x1=10 Marks

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1. i) The pacemaker potential is dueto:
   
   A. FastNa+channel
   

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   B. Na+ entry through funny channels
   
   C. Slow Ca++ efflux
   
   

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   D. Rapidrepolarization


2. ii) True regarding endothelin-1 is all EXCEPT
   
   A. Broncho dilatation
   

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   B. Vasoconstriction
   
   C. Decreased GFR
   
   

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   D. Local regulation


3. iii) Measurement of anatomicdead space is by:
   
   A. O2 breath test
   

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   B. Helium dilution test
   
   C. N2 breath test
   
   

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   D. PCO2


4. iv) Oxygen therapy is least useful in:
   
   A. Anaemia
   

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   B. ARDS
   
   C. Alveolar damage
   
   

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   D. COPD


5. v) In renal disease albumin appears in urine because:
   
   A. Ofits high concentration in plasma
   

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   B. Negative charges in the glomerular wallaredissipated
   
   C. High albumin: globulin ratio
   
   

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   D. Tubular epithelial cells are sensitive to albumin


6. 22i) Which of the following does not form a filtration barrier in nephrons:
   
   A. Podocytes
   

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   B. Mesangium
   
   C. Endothelial cell
   
   

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   D. Basement membrane


7. 22ii) Clathrin is used in: m
   
   A. Receptor mediated endocytosis
   

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   B. Exocytosis
   
   C. Celltocell adhesion
   
   

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   D. Plasma membrane


8. 22 iii) Majorregulator of inter digestive myo-electric complexes:
   
   A. VIP
   

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   B. GIP
   
   C. Motilin
   
   

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   D. Neurotensin


9. 22 iv) Equilibrium potential for an ion is calculated by using:
   
   A. Gibbs Donnan equilibrium
   

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   B. Nernstequation
   
   C. Goldman equation
   
   

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   D. Donnan equilibrium


10. 22v) Glycosylated haemoglobinis known to be a good indicator of:
    
    A. Blood cholesterol levels
    

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    B. Bloodtriglyceride levels
    
    C. Plasma protein levels
    
    

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    D. Bloodglucoselevels

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