Download RGUHS (Rajiv Gandhi University of Health Sciences) A Bachelor of Medicine, Bachelor of Surgery (MBBS) 1st Year (First Year) 1025 RGUHS MBBS Biochemistry Paper II RS4 2023 May Previous Question Paper || RGUHS MBBS first year question papers
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
MBBSPhase? I(CBME)DegreeExamination-06-May-2023
Time:ThreeHours
Max.Marks:100Marks
BIOCHEMISTRY? PAPERI (RS-4)
Q.P.CODE:1025
(QPcontainstwopages)
Youranswersshouldbespecifictothequestions asked
Drawneat,labeled diagrams wherevernecessary
LONGESSAYS
2x10=20Marks
1.
A patient who was suffering with pain abdomen and passing clay coloured stools came to medical OPD for
treatment. On examination therewas yel owish discoloration of sclera. Fol owing investigations a diagnosis of
obstructivejaundicewasmade.
a. Explaintheformationand fateofbilirubin
b. Nametwocauses ofobstructivejaundice
c. Writetheserumand urinaryfindingsinobstructivejaundice
2.
What is semiconservative replication? In which phase of cel cycle replication takes place? Describe
replication in prokaryoteswithneatlylabel ed diagram.
SHORTESSAYS
8x5=40Marks
3.
A7 yearoldboypresented withoedemaand passingfrothyurine.Investigationrevealedsevereproteinuria.
a. Whatisthenormal plasmalevelof total proteinsandalbumin?
b. Nametwootherdisordersassociatedwith hypoalbuminemia
c. Mentionthefunctionsof albumin.
4.
Achild wasrushed totheemergencyward with altered sensorium.On examination, thechild was found tobein
semi comatose stage. Investigations revealed high blood ammonia levels and thecase was suspected to be
urea cycledisorder.
a. Explainureacycle
b. Mentionanytwodisorders ofureacyclewithitsenzymedefect
5.
Explaintertiarystructureofproteins.Listtheforces maintainingtertiarystructure.
6.
Whatispolymerasechainreaction (PCR)?Describethestepsinvolved inPCR.
7.
Enumeratefivetransmethylationreactions and mentiontheirsignificance.
8.
Describe the structure of immunoglobulins. Name any two classes of immunoglobulins and write their
functions.
9.
Whatarenucleotides?Nameanyfourbiologicalimportantnucleotidesandwritetheirimportance.
10.
Listvarious reactiveoxygenspecies. Describethedamages produced byreactiveoxygenspecies.
SHORTANSWERS
10x3=30Marks
11.
Nameblotting techniques.Writetheapplicationsofeachtechnique.
12.
Drawpurineringand indicatethesourcesof carbonand nitrogeninthepurinering.
13.
Whatareproto-oncogenes?Howaretheyactivated?
14.
Mentionthevectors usedinRecombinantDNAtechnologyand writetheirimportance.
15.
WritevandenBerghtestand itsinterpretationinHepaticJaundice.
16.
Whataregrowthfactors?Givetwoexamples.
17.
Writethreedetoxification reactionsbyconjugationmechanism.
18.
Mentiontheadvantagesof automationinclinicalbiochemistrylaboratory.
19.
Writethreereactionsof purinesalvagepathway.
Page 1 of 4
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
20.
WhatareThalasemias?WhatarethedefectsinAlphaandBetaThalasemias?
Page 2 of 4
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
MultipleChoiceQuestions
10x1=10Marks
21i)
Drug which inhibits xanthineoxidaseis
A. Al opurinol
B. Aspirin
C. Colchicine
D. Probenicid
21 i )
Hypoalbuminemia is notseenin
A. Chronicliverdisease
B. Nephroticsyndrome
C. Hemoconcentration
D. Proteinenergymalnutrition
21i i)
Whichofthefol owing isaninhibitorofRNAsynthesis?
A. Rifampicin
B. Ciprofloxacin
C. Novobiocin
D. Adraiamycin
21iv)
Whichofthefol owing isanexampleforsulphurcontainingaminoacid?
A. Phenylalanine
B. Glycine
C. Threonine
D. Cysteine
21 v)
Whichofthefol owing ispurelyKetogenicaminoacid?
A. Proline
B. Glycine
C. Alanine
D. Leucine
22i)
InDNAnumberofhydrogen bondsbetweenGuanineand Cytosineis
A. One
B. Two
C. Three
D. Four
22 i )
Tumormarkerforcolorectalcanceris
A. Carcinoembryonicantigen(CEA)
B. Alpha-fetoprotein
C. Calcitonin
D.
-HCG
22i i)
Nitrogen atoms ofureaarederivedfromammoniaand
A. Asparticacid
B. Alanine
C. Histidine
D. Valine
22iv)
Normalvalueofplasmaosmolalityis
A. 185 to200 mil iosm/kg
B. 285 to300 mil iosm/kg
C. 385 to400 mil iosm/kg
Page 3 of 4
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
D. 485 to500 mil iosm/kg
22 v)
Reproducibilityofresults is bestdescribed as:
A. Sensitivity
B. Specificity
C. Precision
D. Accuracy
******
Page 4 of 4
This post was last modified on 18 November 2023