Download MBBS 1st Year 1024 RGUHS MBBS Biochemistry Paper I RS4 2023 Feb Question Paper

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QP CODE: 1024

Rajiv Gandhi University of Health Sciences, Karnataka

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MBBS Phase- I(CBME) Degree Examination-14-Feb-2023

Time: Three Hours Max. Marks: 100 Marks

BIOCHEMISTRY- PAPERI(RS-4) QP Code: 1024

(QP contains two pages)

Your answers should be specific to the questions asked

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Draw neat labeled diagrams wherever necessary

LONG ESSAYS 2x10=20 Marks

1. A medical student who had an exam on the next day did not eat anything the previous night. Next day morning, he had severe headache and giddiness before exam. His fasting plasma glucose was 48 mg/dl.
   1. Interpret the plasma glucose value
   2. Name the metabolic pathways which maintain blood glucose in fasting state
   3. Explain the metabolic pathway that synthesise glucose from pyruvate

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2. Mention the active form of Vitamin D. Describe the synthesis, biochemical functions and RDA of Vitamin D.

SHORT ESSAYS 8x5=40 Marks

3. A 48-year-old man diagnosed with myocardial infarction (MI) had an altered lipid profile with elevated total cholesterol and LDL cholesterol.
   1. Write the biological reference interval of LDL cholesterol.
   2. Explain the formation of LDL cholesterol.

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   3. Reason out why LDL cholesterol is atherogenic.
4. A 70-year-old man suffered an attack of pneumonia. He found it difficult to breathe and was losing consciousness. His Arterial Blood Gas (ABG) report was as follows: pH=7.1, pCO2 = 52 mmHg, Plasma Bicarbonate (HCO3¯) = 25meq/L.
   1. Interpret the ABG report.
   2. Write the compensatory mechanism in the above acid-base disorder.

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5. Mention biological reference interval for serum calcium. Describe any four functions of calcium.
6. Define Isoenzymes. Mention the Isoenzymes of creatine phosphokinase (CPK) and write their significance.
7. Define Basal Metabolic Rate(BMR). Enumerate the factors affecting BMR.
8. Explain the metabolic adaptations in well-fed state.
9. Explain competitive inhibition of enzymes with two examples.

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10. Explain the functions of peroxisomes and describe their role in fatty acid oxidation.

SHORT ANSWERS 10x3=30Marks

11. What is fatty liver? Mention any two lipotropic factors.
12. What is hyponatremia? List two causes of hyponatremia.
13. Component of oral rehydration solution (ORS) has sodium chloride and glucose. What is purpose of adding glucose in ORS?

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14. Mention any three site specific inhibitors of electron transport chain.
15. Name the enzyme defect in von Gierke' s disease. Write the biochemical alterations in von Gierke' s disease.
16. What is the cause of pellagra? Write the clinical manifestations of pellagra.
17. A diabetic patient was advised not to take polished rice but to take brown rice. Explain the reasons for the same.
18. Mention three homopolysccharides of glucose and write their biological importance.

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19. Write the biochemical defect in Ehler Danlos Syndrome and Osteogenesis imperfecta.
20. Write the biochemical cause of respiratory distress syndrome in premature babies.

Multiple Choice Questions 10x1=10Marks

21. i) Hexokinase belongs to which class of enzymes?
    1. Oxidoreductase
    2. Transferase

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    3. Hydrolase
    4. Lyase
22. ii) Which of the following vitamins is used in the electron transport chain?
    1. Riboflavin
    2. Pantothenic acid

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    3. Pyridoxine
    4. Biotin
23. iii) Glucose and fructose are monosaccharide units of
    1. Lactose
    2. Maltose

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    3. Sucrose
    4. Isomaltose
24. iv) The sugar component of cerebroside is
    1. Galactose
    2. Lactose

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    3. Fructose
    4. Ribose
25. v) The normal Anion gap is
    1. 4-8 mmol/L
    2. 10-14 mmol/L

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    3. 16-20 mmol/L
    4. 22-26 mmol/L

22. i) Limiting amino acid in the protein gelatin is
    1. Lysine
    2. Threonine

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    3. Tryptophan
    4. Methionine
23. ii) Which coenzyme is responsible for carboxylation reactions
    1. Biocytin
    2. FAD

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    3. NAD
    4. TPP
24. iii) Hormone insulin activates which of the following pathway
    1. Glycogenolysis
    2. Gluconeogenesis

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    3. Glycolysis
    4. Lipolysis
25. iv) In Wilson's disease copper accumulates in all of the following tissues EXCEPT
    1. Eyes
    2. Spleen

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    3. Brain
    4. Liver
26. v) The marker enzyme for microsomes is
    1. ATP synthase
    2. Cathepsin

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    3. Glucose-6-phosphatase
    4. Lactate dehydrogenase