QP CODE: 1025
Rajiv Gandhi University of Health Sciences, Karnataka
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MBBS Phase- I(CBME) Degree Examination-16-Feb-2023
Time: Three Hours Max. Marks: 100 Marks
BIOCHEMISTRY- PAPERII (RS-4)
Q.P.CODE: 1025
(QP contains three pages)
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2x10=20 Marks
- A 10 year old boy was brought to the hospital for self-mutilating behaviour and delayed development. His serum uric acid level was 15mg/dl. A provisional diagnosis of Lesch Nyhan syndrome was made.
- Write the biological reference interval for serum uric acid level.
- Name the enzyme defect and the pathway affected in the above disorder.
- Which tissues are dependent on this pathway?
- Enumerate the other causes of hyperuricemia
- What is the role of allopurinol in the treatment of hyperuricemia?
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- Describe the steps of DNA replication in prokaryotes. List the difference between prokaryotic and eukaryotic DNA replication.
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SHORT ESSAYS 8x5=40 Marks
- A 15 year old tribal boy was admitted with complaints of fatigue, recurrent fever and pain in arms and legs. His peripheral blood smear shows sickled erythrocytes and a hemoglobin concentration of 6 gm%.
- Name the molecular defect in this disorder.
- Explain the mechanism of sickling.
- What is the cause of anemia in this condition?
- An intravenous drug user was found to have developed jaundice. Laboratory investigations revealed hepatitis B infection. His total serum bilirubin was 10.2mg/dl.
- What type of jaundice is seen in above case?
- Explain van den Bergh test and write its interpretation in the above case.
- Describe the steps in this polymerase chain reaction (PCR). Name the type of PCR used in the diagnosis of Covid 19.
- Name any three products derived from tyrosine. Describe the metabolic pathway leading to the formation of any one of the product from tyrosine.
- Draw the structure of immunoglobulin G and label it. Enumerate its functions.
- What is lipid peroxidation? Explain the role of antioxidants in scavenging reactive oxygen species.
- Write the steps in the formation of creatine and glutathione from glycine.
- Describe the glomerular function tests.
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SHORT ANSWERS 10x3=30 Marks
- Name three tumor markers and mention their significance.
- What is the enzyme defect in maple syrup urine disease? What are its characteristic features?
- List the adrenal function tests. Mention one disorder associated with abnormal adrenal function.
- Enlist three biologically important peptides and write their functions.
- What are xenobiotics? Write two detoxification reactions by conjugation.
- Name three biologically important nucleotides and mention their importance.
- Mention three advantages of automation in clinical biochemistry laboratory.
- Enlist three post-translational modifications with suitable examples.
- Mention normal albumin/globulin (A/G) ratio. Write two conditions where A/G ratio is altered.
- What is restriction fragment length polymorphism (RFLP). Mention two clinical applications of RFLP.
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Multiple Choice Questions 10x1=10 Marks
- i) All the following are glucogenic amino acids EXCEPT
- Valine
- Phenylalanine
- Glycine
- Leucine
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- ii) N3 of purine ring is donated by
- Aspartate
- Glycine
- Glutamine
- Ammonia
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- iii) Which of the following enzymes is responsible for immortality of cancer cells?
- Telomerase
- RNA polymerase I
- DNA polymerase
- Helicase
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- iv) In which of the following conditions is serum direct bilirubin elevated
- Physiological jaundice in the newborn
- Crigler-Najjar syndrome
- Gilbert's syndrome
- Gallstones
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- v) Enzyme defect in acute intermittent porphyria is
- ALA synthase
- ALA dehydratase
- PBG deaminase
- Uroporphyrinogen decarboxylase
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- i) Closeness of a result to the true value is termed as
- Precision
- Accuracy
- Sensitivity
- Specificity
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- ii) Reference interval for pH of urine is
- 3.5 to 4.5
- 5.5 to 6.5
- 7.5 to 8.5
- 9.5 to 10.5
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- iii) Southern blotting technique is used for detection of
- DNA
- RNA
- Protein
- Lipoprotein
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- iv) Which of the following is an example for acute phase protein?
- Prothrombin
- C-reactive protein
- Lipoprotein A
- Thyroxine binding globulin (TBG)
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- v) Epidermal growth factor (EGF) is produced by
- Platelets
- Monocytes
- Endothelial cells
- Fibroblasts
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This download link is referred from the post: RGUHS MBBS 1st Year Last 15 Years 2010-2025 Previous Question Papers (Rajiv Gandhi University of Health Sciences)