Download (Rajiv Gandhi University of Health Sciences) A Bachelor of Medicine, Bachelor of Surgery (MBBS) 1st Year (First Year) 1025 RGUHS MBBS Biochemistry Paper II RS4 2023 Feb Previous Question Paper || RGUHS MBBS first year question papers
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
MBBSPhase? I(CBME)DegreeExamination-16-Feb-2023
Time:ThreeHours
Max.Marks:100Marks
BIOCHEMISTRY? PAPERI (RS-4)
Q.P.CODE:1025
(QPcontainsthreepages)
Youranswersshouldbespecifictothequestions asked
Drawneat,labeled diagrams wherevernecessary
LONGESSAYS
2x10=20Marks
1.
A 10 year old boy was broughttothehospitalfor self-multilating behaviour and delayed development. His serum
uricacidlevel was 15mg/dl.A provisional diagnosis ofLesch Nyhan syndromewasmade.
a) Writethebiologicalreferenceinterval forserumuricacid level.
b) Nametheenzymedefectand thepathwayaffected intheabovedisorder.
c) Which tissuesaredependentonthispathway?
d) Enumeratetheothercausesofhyperuricemia
e) Whatistheroleof al opurinol in thetreatmentof hyperuricemia?
2.
Describe the steps of DNA replication in prokaryotes. List the difference between prokaryotic and eukaryotic
DNAreplication.
SHORTESSAYS
8x5=40Marks
3.
A 15 year old tribal boy was admitted with complaints of fatigue, recurrent fever and pain in arms and legs. His
peripheralbloodsmearshows sickled erythrocytesand ahemoglobinconcentrationof6 gm%.
a) Namethemoleculardefectinthisdisorder.
b) Explainthemechanismof sickling.
c) Whatisthecauseofanemiainthis condition?
4.
Anintravenous drug userwas found tohavedeveloped jaundice. Laboratoryinvestigations revealed hepatitisB
infection. Histotalserumbilirubinwas10.2mg/dl.
a) Whattypeofjaundiceisseeninabovecase?
b) ExplainvandenBerghtestandwriteitsinterpretation in theabovecase.
5.
Describethesteps in this polymerasechain reaction (PCR). NamethetypeofPCR used in thediagnosis of Covid
19.
6.
Nameanythreeproducts derived fromtyrosine. Describe themetabolicpathwayleading totheformation of any
oneoftheproductfromtyrosine.
7.
DrawthestructureofimmunoglobulinGand labelit.Enumerateits functions.
8.
Whatislipidperoxidation?Explaintheroleofantioxidants inscavengingreactiveoxygen species.
9.
Writethestepsintheformationof creatineand glutathionefromglycine.
10.
Describetheglomerularfunctiontests.
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QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
SHORTANSWERS
10x3=30Marks
11.
Namethreetumormarkersandmentiontheirsignificance.
12.
Whatis theenzymedefectin maplesyrupurinedisease?Whatareits characteristicfeatures?
13.
Listtheadrenalfunctiontests.Mentiononedisorderassociatedwith abnormaladrenalfunction.
14.
Enlistthreebiological yimportantpeptides and writetheirfunctions.
15.
Whatarexenobiotics?Writetwodetoxification reactionsbyconjugation.
16.
Namethreebiological yimportantnucleotides and mentiontheirimportance.
17.
Mentionthreeadvantages ofautomationinclinicalbiochemistrylaboratory.
18.
Enlistthreepost-translationalmodifications withsuitableexamples.
19.
Mentionnormalalbumin/globulin(A/G)ratio. Writetwoconditions whereA/Gratioisaltered.
20.
Whatis restrictionfragmentlengthpolymorphism(RFLP). Mention twoclinicalapplicationsofRFLP.
MultipleChoiceQuestions
10x1=10Marks
21i)
Al thefol owing areglucogenicaminoacids EXCEPT
A. Valine
B. Phenylalanine
C. Glycine
D. Leucine
21 i )
N3ofpurineringisdonatedby
A. Asparate
B. Glycine
C. Glutamine
D. Ammonia
21i i)
Whichofthefol owing enzymesisresponsibleforimmortalityof cancercel s?
A. Telomerase
B. RNApolymeraseI
C. DNApolymerase
D. Helicase
21iv)
Inwhichofthefol owing conditions is serumdirectbilirubinelevated
A. Physiologicaljaundiceinthenewborn
B. Crigler? Naj arsyndrome
C. Gilbert' ssyndrome
D. Gal stones
21 v)
Enzymedefectinacuteintermittentporphyriais
A. ALAsynthase
B. ALAdehydratase
C. PBGdeaminase
D. Uroporphyrinogendecarboxylase
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QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
22i)
Closeness ofaresulttothetruevalueistermedas
A. Precision
B. Accuracy
C. Sensitivity
D. Specificity
22 i )
ReferenceintervalforpHof urineis
A. 3.5 to4.5
B. 5.5 to6.5
C. 7.5 to8.5
D. 9.5 to10.5
22i i)
Southernblotting techniqueis usedfordetection of
A. DNA
B. RNA
C. Protein
D. Lipoprotein
22iv)
Whichofthefol owing isanexampleforacutephaseprotein?
A. Prothrombin
B. C-reactiveprotein
C. LipoproteinA
D. Thyroxinebindingglobulin(TBG)
22 v)
Epidermalgrowth factor(EGF) is produced by
A. Platelets
B. Monocytes
C. Endothelial cel s
D. Fibroblasts
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This post was last modified on 18 November 2023