Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 5th Semester 2017 Summer Pharmaceutical Medicinal Chemistry 1 Question Paper
B.Pharm. Semester?V (C.B.S.) Examination
PHARMACEUTICAL MEDICINAL CHEMISTRY?I
Paper?Z
Time : Three Hours] [Maximum Marks : 80
Note :?(1) Question No. 1 is compulsory.
(2) Attempt any four questions from remaining.
(3) Draw neat labelled diagrams wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
1. Solve any five of the following :
(A) Draw diagram of blood brain barrier and discuss its role.
(B) Draw structure and write chemical name, uses and synthesis of phenobarbitone.
(C) Explain with structures metabolism of paracetamol and write about its actions and toxicity.
(D) What is prodrug ? Discuss principles of prodrug designing with examples.
(E) Discuss oxytocics with examples.
(F) Draw structure and write IUPAC name, uses and synthesis of Xylocaine.
(G) Write note on expectorants and antitussives. 5X4=20
2. Explain metabolism of histamine. Write in detail about chemical classi?cation, mode of action
and side effects of H1 and H2 antihistaminic agents. 15
3. De?ne convulsions. Classify chemically anti?convulsant agents. Write mode of action and synthesis
of one drug from hydontoin class. 15
4. (A) De?ne and classify anti-depressants. 8
(B) Write note on thyroid hormones and antithyroid drugs. 7
5. What are NSAIDs ? Discuss salol principle and write in detail about chemical classi?cation,
mode of action and side effects of NSAIDs. 15
NXO?12541 1 (Contd)
6. (A) Describe phase II metabolism reactions with examples. 7
(B) Write note on anti?asthmatic agents. 8
7. Write notes on any three of the following :
(A) Physicochemical parameters affecting drug action.
(B) Prostaglandins and eicosanoids.
(C) CNS stimulant agents.
(D) Drugs used in Parkinsonism.
(E) Sedatives and hypnotics. 5X3=15
NXO?12541 2 NKT/KS/17/6565
This post was last modified on 19 January 2020