Download RTMNU B.Pharma 6th Semester 2016 Summer Pharmaceutical Medicinal Chemistry 2 Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 6th Semester 2016 Summer Pharmaceutical Medicinal Chemistry 2 Question Paper

TKN/KS/16?7000
Sixth Semester Examination for the Degree
01? Bachelor of Pharmacy
PHARMACEUTICAL MEDICINAL CHEMISTRY- II
Time : Three Hours ]
N. B.
Paper ? 6 T 2
[ Max. Marks : 80
:(1) Question no. 1 is compulsory.
(2) Solve any four questions from the remaining.
(3) Draw neat labeled diagram wherever neces?
sary.
(4) Discuss the reaction, mechanism wherever
necessary.
(5) Assume suitable data wherever necessary.
1. Solve any Five of the following :?
(a)
(b)
(C)
(d)
(e)
(f)
(g)
Write in detail chemistry of tetracycline antibiotics.
Describe malaria life cycle in detail.
Write a brief note on antimetabolites.
Write chemical name structure and synthesis of
Iodoxuridine.
Discuss SAR of chloramphenicol antibiotics.
Write in brief about anthelmintics agents.
Explain computer aided drug designing. 20
2. Classify antibiotics with examples and structure and give
uses of one drug from each class. Discuss stability of [3?
Lactum antibiotics in acidic condition and outline synthesis
of Ampicillin. 15
TKN/KS/16? 7000 Contd.
3. (a) Give classi?cation of antimalarial agent and discuss
SAR of 4?amino quinoline derivatives. 8
(b) What is crystal urea ? How it is prevented ?
Explain with examples. 7
4. What are antineoplastic agent ? Give classi?cation. MOA
and uses of antineoplastic agents and outline synthesis of
chlorambucil. 15
5. (a) Give classi?cation of antimycobacterial agent. Explain
rationale of combinations used in therapy. Give any
one synthesis from it. 8
(b) Classify antiviral drugs with examples. Discuss (hugs
use in AIDS. 7
6. (a) What is Genetic Engineering ? Give its application
in pharmaceutical fonnulations. 8
(b) Give detail account of molecular modeling in drug
design. 7
7. Write notes on any three of the following :?
(a) Antifungal Agent.
(b) Antiamoebic Agent.
(0) Types of QSAR.
(d) Antiseptic and Disinfectant. 15
TKN/KS/16 ? 7000 2 850