Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 6th Semester 2017 Winter Pharmaceutical Medicinal Chemistry 2 Question Paper
B.Pharm. Semester?VI (C.B.S.) Examination
PHARMACEUTICAL MEDICINAL CHEMISTRY?II
Paper?Z
Time : Three Hours] [Maximum Marks : 80
NB. :? (1) Question No. 1 is compulsory.
(2) Solve any FOUR questions from remaining.
(3) Draw neat labelled diagram wherever necessary.
(4) Assume suitable data wherever necessary.
(5) Discuss the reaction, mechanism wherever necessary.
1. Solve any FIVE questions of the following :
(a) Describe in brief about life cycle of malaria.
(b) Write brief introduction to combinatorial chemistry.
(c) Write chemical name, structure and synthesis of Acyclovir.
((1) Discuss SAR of chloramphenicol antibiotics.
(e) Describe the degradation of tetracycline antibiotics.
(1) Write a note on antiamoebic agents.
(g) Explain Computer Aided Drug Design (CADD). 20
2. What are antineoplastic agents ? Give the classi?cation, mechanism of action and uses of antineoplastic
agents and outline the synthesis of chlorambucil. 15
3. (a) Give the classi?cation of antimalarial agent and discuss SAR of 4-amino quinoline derivatives. 7
(b) Discuss the classi?cation mechanism of action and uses of sulfonamide. 8
4. De?ne and classify antibiotics with suitable examples and structure. Give the chemical name and
synthesis of penicillin G. 15
5 . (a) Write about classi?cation of Antitubercular drugs. Explain rationale of combination used in therapy.
Give any one synthesis from it. 8
(b) Classify antiviral drugs with suitable examples. Discuss drugs used in AIDS. 7
6. (a) Give the objectives, general principles, physicochemical properties and common approaches of
drug design. 8
(b) Describe a brief introduction of genetic engineering in medicinal chemistry. 7
7. Write notes on any three of the following :
(a) Methods of QSAR
(b) Antifungal agents
(c) Macrolide antibiotic
(d) Antihelminthic agents. 15
POY?25692
This post was last modified on 19 January 2020