Download RTMNU B.Pharma 7th Semester 2016 Winter Biopharmaceutics and Pharmacokinetics Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 7th Semester 2016 Winter Biopharmaceutics and Pharmacokinetics Question Paper

KNT/KW/ 16/6581
B.Pharm. Seventh Semester (C.B.S.) Examination
BIOPHARMACEUTICS AND PHARMACOKINETICS
Paper?6 (7-T-6)
Time : Three Hours] [Full Marks : 80
NB. :? (1) Q. N0. 1 is compulsory.
(2) Attempt any four questions from remaining.
(3) Draw neat labeled diagram wherever necessary.
(4) Discuss the reaction, mechanism wherever necessary.
(5) Use of electronic calculator, excluding programmable calculator is permitted.
1. Solve any ?ve : 4X5=20
(a)
(b)
(C)
(d)
(e)
(f)
(g)
Enlist the factors affecting drug absorption.
Give various barriers to drug distribution.
Give criteria for Biowavers to bioequivalence study.
Give in-Vitro dissolution testing apparatus mentioned in USP.
What are the important characteristics of microsomal enzymes ?
Write about Non-renal routes of drug elimination.
De?ne Vmax and Km.
2. Give physiology of cell membrane. Describe in detail the mechanism of drug transpOIt from GIT.
3. (a)
(b)
4. (a)
(b)
15
De?ne pharmacokinetics. Give an account on one compartment open model for single oral dose
administration. 8
De?ne ? Absolute Bioavailability and Relative Bioavailability. Describe methods of assessing
Bioavailability. 7
Describe Biopharmaceutical Classi?cation System. Give an account on theories of dissolution.
8
Discuss the factors affecting Gastric Emptying of drugs. 7
NWN?923 8 1 Contd,

5. (a) Give signi?cance of Drug?protein binding. Explain in detail why plasma albumin is considered
as an important protein for drug binding. 8
(b) Give various factors affecting drug metabolism. Describe in brief Extraction Ratio and F irst?pass
Effect. 7
6. (a) Describe zero order kinetic process with suitable example. Add an account on in-Vitro, in-Vivo
correlation. g
(b) Describe non-oral routes of drug absorption. 7
7. Write short notes on (any three) :
(a) Michaeles Menton equation.
(b) Purpose of Bioavailability testing
(0) Pathways of metabolism
((1) Bioequivalence study. 5X3=15
NWN?9238 2 KNT/KW/16/6581