Download RTMNU B.Pharma 2nd Semester 2017 Winter Pharmaceutical Analysis 1 Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 2nd Semester 2017 Winter Pharmaceutical Analysis 1 Question Paper

NRJ/KW/17/4264
B.Pharm Second Semester (C.B.S.) Examination
PHARMACEUTICAL ANALYSIS?I
Paper?4
Time : Three Hours] [Maximum Marks : 80
NB. :? (1) Question N0. 1 is compulsory.
(2) Solve any FOUR questions from the remaining.
(3) Draw neat labelled diagrams wherever necessary.
(4) Use of electronic calculator is permitted.
(5) Assume suitable data wherever necessary.
1. Answer any FIVE 0f the following :
(a)
(b)
(C)
(d)
(e)
(f)
(g)
2. (a)
(b)
Explain why an aqueous solution of sodium chloride is neutral whereas solution of sodium acetate
is basic in nature ?
Comment on the use of acetic anhydride in the preparation of 0.1 M acetous perchloric acid
solution.
Explain why solution of sodium thiosulphate is prepared in freshly boiled and cooled water ?
Explain why small excess of precipitating agent be added but large excess should be avoided in
gravimetric analysis.
Explain the reasons of indicator color fading at end point in chloride determination by Volhard?s
method. Suggest the ways to overcome it.
Explain why complexometric titrations should be performed at suitable pH in properly buffered
media.
What is molarity and normality ? Compare their advantages and drawbacks. 5X4=20
Explain the neutralisation curves of different acid-base titrations and suggest suitable indicators
for detection of end point. 10
Describe the principle and procedure of assay of ammonium chloride LP. 5
3. What are non-aqueous titrations ? Give their advantages and limitations. Explain preparation, standardisation
and storage of 0.1 M sodium methoxide solution. 15
4. Explain the theory of internal redox indicators and justify the use of ferroin as suitable indicator in
titration of ferrous sulphate with ceric ammonium sulphate on the basis of redox titration curve.
5 . (a)
(b)
6. (a)
(b)
15
Discuss the experimental conditions for formation of course crystalline precipitate in gravimetry.
How will you minimise the contamination of precipitate ? 8
Describe a Mohr?s method of halide determination and comment on the theoretical and practical
concentration of indicator to be used in it. 7
What are complexes, chelates and sequestering agents ? Explain why EDTA is considered to be
very versatile titrant in complexometry. 7
Describe various means of improving the selectivity of complexometric titrations. How will you
determine the contents of aluminium and magnesium in admixture ? 8
7. Write notes on any THREE 0f the following :
(a)
(b)
(C)
(d)
(e)
Non-aqueous titrimetric assay of ephedrine hydrochloride
Thermogravimetry
Theory of adsorption indicators
Accuracy, precision and errors
Filtration and washing of precipitate in gravimetry. 5X3=15
POY?25682