Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1162PCI Advanced Medicinal Chemistry Question Paper

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Code No. 1162/PClI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination, February 2018

Subject: Advanced Medicinal Chemistry

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. 1. Give an account on various types of drug targets

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   2. Discuss types of Receptors and their activation mechanism. (6+9)
2. 1. Discuss the various approaches used in the design of analogues from Lead Compound
   2. Give an account on pro-moieties for various functional groups in prodrug design. (8+7)

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3. 1. Classify antihypertensive drugs with example.
   2. Explain how the chirality of a drug molecule influences its pharmacokinetic properties? (8+7)
4. 1. Define drug resistance and discuss the mechanisms of antibiotic drug resistance.
   2. Classify anti-convulsants with examples and discuss the SAR of barbiturates. (8+7)

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5. 1. Give an account on enzyme inhibitors in medicine and basic research
   2. Explain about Non-covalently binding enzyme inhibitors. (8+7)
6. 1. Define peptidomimetics and discuss the advantages of them over peptide drugs.

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   2. Explain the various approaches involved in peptidomimetic drug design. (8+7)
7. 1. Discuss the chemistry of prostaglandins and leukotrienes.
   2. Explain the concept of bio-isosterism. (8+7)

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8. Write a short note on
   1. ACE inhibitors
   2. HIV protease inhibitors (8+7)

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