Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1162PCI Advanced Medicinal Chemistry Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2018 1162PCI Advanced Medicinal Chemistry Previous Question Paper

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Code No. 1162/PCI
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination,
February 2018
Subject: Advanced Medicinal Chemistry
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 a) Give an accnt on varis types of drug targets .
b) Discuss types of Receptors and their activation mechanism. (6+9)
2 a) Discuss the varis approaches used in the design of analogues from Lead
Compnd .
b) Give an accnt on pro -moieties for varis functional grps in prodrug
design. (8+7)
3 a) Classify antihypertensive drugs with example.
b) Explain how the chirality of a drug molecule influences it?s pharmacokinetic
properties ? (8+7)
4 a) Define drug resistance and discuss the mechanisms of antibiotic drug resistance.
b) Classify anti convulsants with examples and discuss the SAR of barbiturates. (8+7)
5 a) Give an accnt on enzyme inhibitors in medicine and basic research .
b) Explain abt Non -covalently binding enzyme inhibitors. (8+7)
6 a) Define peptidomimetics and discuss the advantages of them over peptide drugs.
b) Explain the varis approaches involved in peptidomimetic drug design . (8+7)
7 a) Discuss the chemistry of prostaglandins and leukotrienes.
b) Explain the concept of bio-isosterism. (8+7)
8 Write a short note on
a) ACE inhibitors
b) HIV protease inhibitors (8+7)
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This post was last modified on 19 July 2020