Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13308 PCI Advanced Medicinal Chemistry Question Paper

FirstRanker.com

Code No. 13308 / PCI

FACULTY OF PHARMACY

--- Content provided by FirstRanker.com ---

M. Pharmacy (Pharmaceutical Chemistry) | — Semester (PCIl) (Suppl.)

Examination, August 2019

Subject : Advanced Medicinal Chemistry

Time : 3 hrs Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

--- Content provided by‍ FirstRanker.com ---

1. a) What are leads? Discuss the concept of lead discovery.
   b) Discuss the criteria for the identification of target and its validation in drug discovery. 8+7
2. a) Explain the concepts of prodrug design and discuss its applications.
   b) Write a note on resistance to antibiotics and anti cancer drugs. 9+6
3. a) Give the classification of antineoplastic drugs with suitable examples.
   

   --- Content provided by FirstRanker.com ---

   b) Write a note on HIV protease inhibitors. 9+6
4. Enumerate various classes of enzyme inhibitors with suitable examples and discuss about any one class of enzyme inhibitors. 15
5. a) Define and differentiate peptide drugs and peptidomimetics with examples and discuss the concept of peptidomimetic drug design.
   b) Discuss the chemistry of prostaglandin. 8+7
6. a) Classify Antihypertensive drugs with suitable examples and give the synthesis of Diltiazem.
   

   --- Content provided by FirstRanker.com ---

   b) Explain how the chirality of the drug influences the biological activity. 9+6
7. Write a note on :
   a) Lead optimization
   b) Molecular modifications in analogue design 7+8
8. a) Write a note on AchE-inhibitors
   

   --- Content provided by‍ FirstRanker.com ---

   b) Write a note on cyclooxygenase inhibitors 8+7

FirstRanker.com