Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13308 PCI Advanced Medicinal Chemistry Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2019 13308 PCI Advanced Medicinal Chemistry Previous Question Paper

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Code No. 13308 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I ? Semester (PCI) (Suppl.)
Examination, August 2019
Subject : Advanced Medicinal Chemistry
Time : 3 hrs Max. Marks : 75
Note : Answer any FIVE questions. All questions carry equal marks.
1 a) What are leads? Discuss the concept of lead discovery.
b) Discuss the criteria for the identification of target and its validation in drug
discovery. 8+7
2 a) Explain the concepts of prodrug design and discuss its applications.
b) Write a note on resistance to antibiotics and anti cancer drugs. 9+6
3 a) Give the classification of antineoplastic drugs with suitable examples.
b) Write a note on HIV protease inhibitors. 9+6
4 Enumerate varis classes o f enzyme inhibitors with suitable examples and discuss
abt any one class of enzyme inhibitors. 15
5 a) Define and differentiate peptide drugs and peptidomimetics with examples and
discuss the concept of peptidomimetic drug design.
b) Discuss the chemistry of prostaglandin. 8+7
6 a) Classify Antihypertensive drugs with suitable examples and give the synthesis of
Diltiazem.
b) Explain how the chirality of the drug influences the biological activity. 9+6
7 Write a note on :
a) Lead optimization
b) Molecular modifications in analogue design 7+8
8 a) Write a note on AchE inhibitors
b) Write a note on cyclooxygenase inhibitors 8+7
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