Download OU M.Pharma Ph.Chemistry 1st Sem 2019 13309 PCI Chemistry Of Natural Products Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2019 13309 PCI Chemistry Of Natural Products Previous Question Paper

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Code No. 13309 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I ? Semester (Suppl.) Examination,
August 2019
Subject : Chemistry of Natural Products
Time : 3 hrs Max. Marks : 75
Note : Answer any FIVE questions. All questions carry equal marks.
1 a) Discuss the structural elucidation of reserpine.
b) Give classification, isolation and biological activity of alkaloids. 9+6
2 How natural products acted as leads for the following classes of drugs? Explain.
a) Drugs affecting CNS
b) Anticancer drugs
c) Cardiovascular drugs 5+5+5
3 a) Discus the general methods to elucidate the structure of terpenoids.
b) Write the structural elucidation of menthol. 8+7
4 a) Give the chemistry and physiological significance of Vitamin A, Vitamin C and
Folic acid.
b) Explain how recombinant DNA technology helped in new drug discovery. 8+7
5 a) Write a note on Sapogenins and cardiac glycosides.
b) Discuss chemistry of contraceptive agents.
c) Discuss clinical applications and recent advances in gene therapy. 5+5+5
6 How do y characterize the follo wing natural compnds using IR,
1
H NMR and
13
C
NMR spectral values? Give approximate spectral values.
a) Quercetin b) Vitamin-D
c) Morphine d) Benzyl penicillin
e) Digoxin 5 x 3 = 15
7 a) List t the active constituents present in the following crude drugs with their
structures.
i) Curcuma longa linn ii) Trigonella foenumgraccum
iii) Pterocarpus marsupiam iv) Swertia chirata 4 x 2 = 8
b) Write in brief the structural elucidation of phytol. 7
8 Write a note on : (5+5+5)
a) Hofmann exhaustive methylation
b) Stereochemistry and nomenclature of steroids
c) Chemistry of flavanoids
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