Download OU M.Pharma Ph.Chemistry 1st Sem 2020 6111PCI Advanced Medicinal Chemistry Question Paper

Code No: 6111/PCI

FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main & Backlog)

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Examination, January 2020

Subject: Advanced Medicinal Chemistry

Time: 3 Hrs Max. Marks: 75

Note: Answer any Five questions. All questions carry equal marks

1. 1. Give an account on various types of drug targets.

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   2. Discuss theories of drug receptor interactions. (6+9)
2. 1. Discuss about lead optimization in drug discovery.
   2. Give an account on pro-moieties for various functional groups in prodrug design. (8+7)

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3. 1. What is hypertension? Give the classification of Antihypertensive agents with examples.
   2. Explain how the chirality of drugs is important for its pharmacological activity? (8+7)
4. 1. Define drug resistance and discuss the mechanisms of antibiotic drug resistance.
   2. Classify anti-convulsants with examples and discuss the SAR of Benzodiazepines. (8+7)

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5. 1. Give an account on enzyme inhibitors in medicine and basic research.
   2. Discuss about Non-covalently binding enzyme inhibitors and their pharmacological significance. (8+7)
6. 1. Define peptidomimetics and discuss the advantages of them over peptide drugs

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   2. Discuss about unnatural amino acids used in peptidomimetic drug design. (8+7)
7. 1. Discuss the chemistry of prostaglandins and leukotrienes.
   2. Explain the concept of bio-isosterism. (8+7)

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8. Write a short note on : (8+7)

   1. Beta Blockers
   2. HIV protease inhibitors

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