Download OU M.Pharma Ph.Chemistry 1st Sem 2020 6111PCI Advanced Medicinal Chemistry Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2020 6111PCI Advanced Medicinal Chemistry Previous Question Paper

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Code No: 6111/PCI
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main & Backlog)
Examination, January 2020
Subject: Advanced Medicinal Chemistry
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five questions. All questions carry equal marks

1 a) Give an accnt on varis types of drug targets.
b) Discuss theories of drug receptor interactions. (6+9)

2 a) Discuss abt lead optimiza tion in drug discovery.
b) Give an accnt on pro -moieties for varis functional grps in prodrug
design. (8+7)

3 a) What is hypertension? Give the classification of Antihypertensive agents with
b) Explain how the chirality of drugs is important for its pharmacological activity? (8+7)

4 a) Define drug resistance and discuss the mechanisms of antibiotic drug resistance.
b) Classify anti convulsants with examples and discuss the SAR of
Benzodiazepines. (8+7)

5 a) Give an accnt on enzyme inhibitors in medicine and basic research.
b) Discuss abt Non -covalently binding enzyme inhibitors and their
pharmacological significance. (8+7)

6 a) Define peptidomimetics and discuss the advantages of them over peptide drugs
b) Discuss abt unnatural amino acids used in peptidomimetic drug design. (8+7)

7 a) Discuss the chemistry of prostaglandins and leukotrienes.
b) Explain the concept of bio-isosterism. (8+7)

8 Write a short note on : (8+7)
a) Beta Blockers
b) HIV protease inhibitors

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This post was last modified on 19 July 2020