Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1163PCI Chemistry Of Natural Products Question Paper

FirstRanker.com

Code No. 1163/PCI

FACULTY OF PHARMACY

--- Content provided by‌ FirstRanker.com ---

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Main) Examination, February 2018

Subject: Chemistry of Natural Products

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. Explain how natural products acted as lead molecules while designing drugs? Explain by taking any three classes of drugs. (15)

--- Content provided by‍ FirstRanker.com ---

2. (a) Write the classification and biological activity of alkaloids.
   (b) Discuss the structural elucidation of Reserpine (OR) Ephedrine. (5+10)
3. (a) Discuss the stereochemistry and nomenclature of steroids.
   (b) Write a note on contraceptive steroids.
   (c) Explain structural elucidation of Quercetin (5+5+5)

--- Content provided by‍ FirstRanker.com ---

4. (a) Explain isoprene rule and discuss general methods for structural elucidation of terpenoids.
   (b) Discuss the chemistry and physiological significance of Vitamin A. (10+5)
5. Discuss the structural elucidation of any one monoterpenoid and one Diterpenoid. (15)
6. How do you characterize the structure of following natural compounds using IR, ¹HNMR and ¹³CNMR ? (Give approximate spectral values).
   (a) Penicillin -G
   

   --- Content provided by‌ FirstRanker.com ---

   (b) Morphine
   (c) Quercetin
   (d) Digoxin
   (e) Vitamin — D (5x3)
7. (a) Write a note on Recombinant DNA technology and how it helped in new drug discovery?
   

   --- Content provided by‌ FirstRanker.com ---

   (b) Write down the active constituents present in the following crude drugs by giving the structures for two compounds each:
   (i) Gymnema sylvestre (ii) Trigonella foenumgraecum
   (iii) Phyllanthus niruri ~ (iv) Curcuma longa (7+8)
8. Write a note on :
   (a) Anti inflammatory steroids
   

   --- Content provided by‌ FirstRanker.com ---

   (b) Gene therapy
   (c) Chemistry and biological significance of Vitamin B₆, B₁₂ and B₂

FirstRanker.com