Download OU M.Pharma Ph.Chemistry 1st Sem 2018 1294PCI Advanced Medicinal Chemistry Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 1st Sem 2018 1294PCI Advanced Medicinal Chemistry Previous Question Paper

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Code No. 1294/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I-Semester (PCI) (Suppl.) Examination,
August 2018
Subject: Advanced Medicinal Chemistry
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 a) Discuss abt varis stages involved in the drug discovery.
b) Explain the theories of drug receptor interactions. (8+7)
2 a) Define prodrug and discuss the applications of prodrugs with suitable examples.
b) Discuss the strategies to overcome the drug resistance to antibiotics. (9+6)
3 a) Give the classification of H1 and H2 histamine receptor antagonists with suitable
examples.
c) Discuss how chirality of drug molecule influences the pharmacological
action? (9+6)
4 a) Give the classification of enzyme inhibitors with suitable examples.
b) Discuss the rational design of reversible enzyme inhibitors. (10+5)
5 a) Define peptidomimetics and discuss the varis types of peptidomimetics.
b) Explain the varis approaches used in peptide modifications in peptidomimetics
design. (7+8)
6 a) Classify antineoplastic drugs with suitable examples and discuss the mechanism
of action of methotrexate and chlorambucil.
b) Discuss the chemistry of prostaglandins. Write the structures of therapeutically
useful prostaglandins. (9+6)
7 Write a note on
a) Srces for lead identification
b) Drug receptor interactions (7+8)
8 a) What are bio-isosters? Discuss their applications in analogue design.
b) Write a note on cyclooxygenase inhibitors. (8+7)
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