Download OU M.Pharma Ph.Analysis 2nd Sem 2018 5bc511ef7595 p 17 Question Paper

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FACULTY OF PHARMACY

M. Pharmacy (Pharm. Analysis) II-Semester (PCI) (Main) Examination, August 2018

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Subject: Advance Instrumental Analysis

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. a. Explain about various types of columns and column problems in HPLC. (9)
   b. Write the principle and advantages of Ultra and Nano liquid chromatography? (6)

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2. a. Discuss about ion exchange chromatography and write in detail about its applications? (7)
   b. Explain the various components of HPTLC and write its advantages over column chromatography? (8)
3. a. Write about various detectors used in GLC? (10)
   b. Explain the principle and basic configuration of capillary electrophoresis? (5)
4. Elaborate with a neat sketch, the instrumentation of mass spectrometry? (15)

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5. a. What do you mean by chemical shift? Explain the various factors influencing it? (10)
   b. Explain about nuclear double resonance and its applications? (5)
6. a. Mention various tandem MS/MS systems and explain any one briefly with a neat sketch? (9)
   b. Discuss the principle and applications of size exclusion chromatography? (6)
7. a. Explain about preparative HPLC? (7)
   

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   b. Discuss about FT NMR with reference to C¹³ NMR (8)
8. a. Explain about LC -NMR hyphenation. (9)
   b. Write about fragmentation rules in MS? (6)

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