Download OU M.Pharma Ph.Analysis 2nd Sem 2019 13180PCI Modern Bio Analytical Techniques Question Paper

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Code No. 13180/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Analysis) II-Semester (PCI) (Suppl.) Examination, February 2019

Subject: Modern Bio Analytical Techniques

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. Write about the following sample preparation techniques.

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   1. Solid phase extraction
   2. Liquid Liquid extraction

   (c) Explain the Bioanalytical method validation as per USFDA guidelines.

2. (a) Discuss about Biopharmaceutical factors affecting drug bioavailability.

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   (b) Write the Biopharmaceutics classification system defined by FDA.

3. (a) What is enzyme inhibition? Discuss about drug interactions due to enzyme inhibition with examples.

   (b) Discuss about drug -protein binding interactions with examples.

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4. (a) Write about principles, instrumentation and applications of flow cytometry.

   (b) Write about cryopreservation and storage of cells.

5. (a) Explain different study designs in bioequivalence studies.

   (b) Differentiate absolute and relative bioavailability with illustrative examples and equations.

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6. (a) Discuss the importance and applications of Toxicokinetic studies.

   (b) Write about basic equipments used in cell culture lab.

7. (a) Discuss about different approaches for identification of metabolites.

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   (b) Write short note on clinical significance of bioequivalence studies.

8. (a) Describe the compendia methods of dissolution testing.

   (b) Write about in-vivo and in-vitro methods for checking cellular permeability of new drug products.

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