Download OU M.Pharma Ph.Chemistry 2nd Sem 2019 13168PCI Advanced Organic Chemistry Ii Question Paper

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Code No. 13168/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharm. Chemistry) II-Semester (PCII) (Suppl.) Examination, February 2019

Subject : Advanced Organic Chemistry-II

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. a) Discuss the Principle and applications of microwave irradiation reactions
   

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   b) Explain the basic principles of green chemistry in organic synthesis. (7+8)
2. Discuss asymmetric synthesis using chiral pool, chiral auxiliaries, chiral catalysts and chiral solvents with suitable examples
3. a) Write a note on transition — metal catalysed reactions in organic synthesis
   b) What is biocatalysis? Describe the organic synthesis by using enzymes.
   c) Discuss hydrogenation reactions using homogenous catalysts.

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4. Discuss electro cyclic and sigma tropic reactions in presence of heat and light with suitable examples
5. a) Write a note on solid phase combinatorial synthesis.
   b) Discuss various solid supports, linkers, protecting and deprotecting groups used in solid-phase peptide synthesis
6. a) Discuss any two methods of resolution of racemic mixtures. 9
   b) Discuss sequence rules of R & S configuration with suitable examples. Explain how it is different from Fisher's D & L notations? 6

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7. Write a note on
   a) Photo — addition reactions
   b) Phase — transfer catalysis
   c) Ultra sound assisted reactions (5+5+5)
8. a) Discuss cycloaddition reactions with mechanism and stereochemistry in presence of heat and light.
   

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   b) Discuss coupling reactions in peptide synthesis (8+7)