Download OU M.Pharma Ph.Chemistry 2nd Sem 2019 13325PCI Computer Aided Drug Design Question Paper

Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 2nd Semester 2019 13325PCI Computer Aided Drug Design Previous Question Paper

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Code No. 13325/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main) Examination,
August 2019
Subject: Computer Aided Drug Design
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 (a) Discuss in detail abt varis parameters used in QSAR.
(b) How substituent hydrophobicity constant is used in the QSAR? Discuss
with an example equation. (10+5)
2 (a) What is Hansch analysis and Discuss how it is used in predicting the
biological activity?
(b) Give the advantages and disadvantages of Hansch analysis. (9+6)
3 (a) What is quantum mechanics? Describe the use of quantum mechanics
in drug design.
(b) What is molecular docking? Discuss the steps involved in molecular
docking? (8+7)
4 (a) What is Homology modeling? Discuss its importance in drug design. (8+7)
(b) Write a note on fragment based drug design.
5 (a) What is known as pharmacophore? Discuss the concept of Pharmacophore
based virtual screening.
(b) Write a note on pharmacophore modeling. (8+7)
6 (a) Write a note on Scoring techniques in Molecular docking.
(b) Discuss varis models for predicting ADMET properties . (7+8)
7 (a) What is virtual screening ? Discuss abt druglikeness screening .
(b) Write a note on Privileged structures. (8+7)
8 (a) What is bioactive conformation ? Discuss varis energy minimization
techniques. (8+7)
(b) Write a note on application of Free Wilson analysis in drug design.
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