Download OU M.Pharma Pharmaceutics 2nd Sem 2019 13320PCI Advanced Biopharmaceutics And Pharmacokinetics Question Paper

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Code. No: 13320/PCI

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FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Main) Examination, August 2019

Subject : Advanced Biopharmaceutics and Pharmacokinetics

Time: 3 Hrs Max. Marks: 75

Note: Answer any Five Questions. All Questions Carry Equal Marks.

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1. (a) Explain in detail various factors affecting dissolution. 10
   (b) Write a note on Biopharmaceutics classification system 5
2. (a) Explain various causes of nonlinearity. Write Michaels Menten equation and explain the terms therein 8
   (b) Write important characteristics of carrier mediated transport. Compare facilitated diffusion and active transports 7
3. Write in detail about:
   

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   (a) Clearance 5
   (b) Physiological model 5
   (c) Absolute & relative bioavailability 5
4. (a) List compendia methods of dissolution. Explain alternative methods of dissolution testing 8
   (b) Write in detail about in vitro in vivo correlation 7

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5. (a) Write the significance of absorption rate constant. How do you determine Ka by Wagner nelson method? 8
   (b) Explain various methods to study drug permeability 7
6. (a) Oral bolus dose: 10mg Drug follows one compartment model, assume that drug is 80% absorbed. Following is blood data.
   Time (hrs) | 0.25 | 0.5 | 0.75 | 1.00 | 2 | 4 | 6 | 10 | 14 | 20
   Concentration (ng/ml) | 2.83 | 5.43 | 7.75 | 9.84 | 16.2 | 22.15 | 23.01 | 19.09 | 13.9 | 7.97
   

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   Determine elimination constant, Ka, t1/2, tmax, Cmax, Vd and Clearance 15
7. (a) Explain pharmacokinetic drug interactions with examples 8
   (b) Write a note on biosimilars 7
8. (a) Discuss briefly the influence of pharmaceutical excipients on drug bioavailability 7
   (b) Explain the application of pharmacokinetics in design of modified release dosage forms 8

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