Download OU M.Pharma Pharmaceutics 2nd Sem 2019 13320PCI Advanced Biopharmaceutics And Pharmacokinetics Question Paper

Download OU (Osmania University) M.Pharma-Pharmaceutics (Master of Pharmacy) 2nd Semester 2019 13320PCI Advanced Biopharmaceutics And Pharmacokinetics Previous Question Paper

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Code. No: 13320/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Main) Examination,
August 2019
Subject : Advanced Biopharmaceutics and Pharmacokinetics
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five Questions. All Questions Carry Equal Marks.
1. (a) Explain in detail varis factors affecting dissolution. 10
(b) Write a note on Biopharmaceutics classification system 5
2. (a) Explain varis causes of nonlinearity. Write Michaels Menten equation and explain the
terms there in 8
(b) Write important characteristics of carrier mediated transport Compare facilitated
diffusion and active transports 7
3. Write in detail abt
(a) Clearance 5
(b) Physiological model 5
(c) Absolute & relative bioavailability 5
4. (a) List compendia methods of dissolution Explain alterative methods of dissolution
testing 8
(b) Write in detail abt in vitro in vivo correlation 7
5. (a) Write the significance of absorption rate constant. How do y determine Ka by
Wagner nelson method, 8
(b) Explain varis methods to study drug permeability 7
6. (a) Oral bolus dose: 10mg Drug follows one compartment model, assume that drug is
80% absorbed Following is blood data.
Time (hrs) 0.25 0.5 0.75 1.00 2 4 6 10 14 20
Concentration
(ng/ml)
2.83 5.43 7.75 9.84 16.2 22.15 23.01 19.09 13.9 7.97
Determine elimination constant, Ka, t1/2 t
max
, C
max
, V
d
and Clearance 15
7. (a) Explain pharmacokinetic drug interactions with examples 8
(b) Write a note on biosimilars 7
8. (a) Discuss briefly the influence of pharmaceutical excipients on drug bioavailability 7
(b) Explain the application of pharmacokinetic in design of modified release dosage
forms 8
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