Download OU (Osmania University) M.Pharma-Pharmaceutics (Master of Pharmacy) 2nd Semester 2020 6107PCI Advanced Biopharmaceutics And Pharmacokinetics Previous Question Paper

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Code. No: 6107/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Suppl.) Examination,
January 2020

Subject : Advanced Biopharmaceutics and Pharmacokinetics
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five Questions. All Questions Carry Equal Marks.

1. (a) Discuss abt the theories proposed for the dissolution process and the factors
affecting dissolution. 10
(b) What is in-vitro-in-vivo correlations (IVIVC) and explain in brief 5

2. (a) Write in details abt factor affecting dosage forms in drug absorption 10
(b) State and Explain the Noyes-Whitney equation 5

3. Write notes on
(a) p
H
-partition hypothesis and its limitations 8
(b) Explain the biopharmaceutical factor affecting drug bioavailability 7

4. (a) Explain the pharmacokinetic parameters of a drug which follows one compartment
open model when given by intravens bolus with relevant mathematical equations. 8
(b) Explain the varis methods for assessment of bioavailability. 7

5. (a) Define Non-Linear pharmacokinetics. How do y estimate the pharmacokinetics
parameters (Kmax and Vmax) by using Michaelis - Menten equation 10
(b) Explain the biopharmaceutical classification system (BCS) with examples and what
are its application. 5

6. (a) Write a note on varis study design s used for bioequivalence studies 8
(b) Write the application of pharmacokinetics in monoclonal antibodies and gene
therapies 7

7. (a) Explain the varis methods for determining absorption of drugs in-vitro, in-situ and
in-vivo and their their correlation with examples. 10
(b) Following a 650 mg I.V.bolus dose of a drug to a 65kg subject, the plasma drug
concentration was fnd to decline biexponentially. The equation, that best
described the drug kinetic was; C=76
e-14t
+ 33
e-3t
. Calculate the following parameters
Vc, Vp, Vd.ss, Vd. area and KE etc.

8. A dose of cirprofloxaction 250 mg I.V. bolus was administered to a patient and the
plasma concentration vs time data is obtained. Assume the drug follows two
compartment open model. Calculate all possible pharmacokinetic parameters.
Time (hrs) 0.25 0.5 0.75 1.5 2 2.5 3 5 6 7
Plasma Conc. ( ? g/ml) 5.38 4.33 3.5 2.99 2.12 1.70 1.43 1.05 0.80 0.70

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