Download OU M.Pharma Pharmaceutics 2nd Sem 2018 1210PCI Advance Biopharmace. And Pharmacokinetics Question Paper

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FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Main) Examination, August 2018

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Subject: Advance Biopharmaceutics & Pharmacokinetics

Time: 3 Hrs Max. Marks : 75

Note: Answer any five questions. All questions carry equal marks.

1. (a) Derive expressions for Cmax and tmax for one compartment open model, extra vascular administration. (8)
   (b) Explain with examples cytochrome p450 based drug interactions. (7)

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2. (a) What are the different methods for assessment of bioavailability? (8)
   (b) What are the special concerns in bioavailability and bioequivalence studies. (7)
3. (a) Write the significance of different volumes of distribution in two compartment model. (5)
   (b) Write a note on volume of distribution and clearance. (10)
4. (a) Explain various methods to study drug permeability. (7)
   

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   (b) Write about IVIVC. (8)
5. (a) Derive Michaelis-Menten equation. How do you estimate Km and Vmax. (10)
   (b) How do you compare dissolution profiles? (5)
6. (a) Explain the applications of pharmacokinetic principles in controlled release dosage forms. (8)
   (b) Write a note on micro climate intracellular pH and tight junction complex. (7)

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7. (a) Enumerate physicochemical factors of the drug affecting dissolution. (7)
   (b) Explain the kinetics of IV infusion for one compartment model. (8)
8. (a) Explain various cross over designs in bioequivalence studies. (7)
   (b) Write in detail about compartment models. (8)

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