Download OU M.Pharma Pharmacology 2nd Sem 2019 13328 PCI Pharmacological And Toxicological Screening Methods ? Ii Question Paper

Download OU (Osmania University) M.Pharma-Pharmacology (Master of Pharmacy) 2nd Semester 2019 13328 PCI Pharmacological And Toxicological Screening Methods ? Ii Previous Question Paper

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Code No. 13328 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II ? Semester (PCI) (Main) Examination,
August 2019
Subject: Pharmacological & Toxicological Screening Methods ? II
Time: 3 Hrs Max.Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Discuss in detail the determination of LD
50
in acute toxicity testing of drugs as per
OECD. What is its significance? 15
2 Write short notes on:
a) Acute eye irritation testing. 8
b) Dermal toxicity studies. 7
3 What is carcinogenesis? How do y test the compnds for carcinogenicity? Give
details. 15
4 Define IND. Discuss the studies needed for IND submission. 15
5 Define safety pharmacology? Explain the scope, importance and principles of safety
pharmacology. 15
6 Write short notes on:
a) Alternatives to animal toxicity testing 8
b) Applications of toxicokinetic studies. 7
7 Explain the importance of OECD principles of good Laboratory Practice (GCP) in drug
development. 15
8 Write notes on:
a) Ames test for genotoxicity 5
b) Teratogenicity studies. 10
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