Download OU M.Pharma Pharmacology 2nd Sem 2020 6122 PCI Pharmacological And Toxicological Screening Methods ? Ii Question Paper

Download OU (Osmania University) M.Pharma-Pharmacology (Master of Pharmacy) 2nd Semester 2020 6122 PCI Pharmacological And Toxicological Screening Methods ? Ii Previous Question Paper

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Code No. 6122 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II ? Semester (PCI) (Suppl.) Examination,
January 2020
Subject: Pharmacological & Toxicological Screening Methods ? II
Time: 3 Hrs Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.
1 Discuss the ICH guidelines for toxicity studies in detail. 15
2 a) Write abt varis studies required for IND submission. 7
b) Write the role and responsibilities of
i) Sponsorer 4
ii) Investigator in clinical research 4
3 Write a note on:
a) Teratogenecity studies 8
b) In vivo carcinogenicity studies. 7
4 a) Describe the spermatogenesis 7
b) Explain the possible toxicity effects on reproductive endocrinology. 8
5 a) Explain the principles of GLP (Good Laboratory Practice) as per OECD guidelines
for toxicity studies. 15

6 Write a note on:
a) Chromosomal aberration test 7
b) In vivo micronucleus test 8

7 a) Explain principles of toxicokinetics. 8
b) Write a note on dermal toxicity testing. 7

8 a) Explain the varis factors influencing the toxicity evaluation studies with animal
models. 8
b) Write abt acute, sub -acute and chronic toxicity studies as per OECD guidelines. 7
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