Download OU M.Pharma Pharmacology 2nd Sem 2020 6123 PCI Principles Of Drug Discovery Question Paper

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Code No. 6123 / PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmacology) II - Semester (PCI) (Suppl.) Examination, January 2020

Subject: Principles of Drug Discovery

Time: 3 Hours Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. a) Discuss the role of transgenic animals in drug discovery. 10
   

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   b) Explain in brief the role of genomics in target identification. 5
2. a) Describe the methods of lead optimization. 8
   b) Write a note on protein structure prediction and molecular modelling. 7
3. a) Write a note on 3D QSAR. 7
   b) Explain in brief abt electronic parameters used in QSAR. 8

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4. a) Explain abt the identification of pharmacophore in computer aided drug design. 8
   b) Write a note on CoMSIA. 7
5. a) What do y understand abt De Novo drug design? 7
   b) Explain the role of physicochemical properties in relation to biological activity and drug design. 8
6. a) Write a note on design of pro-drug with their application. 8
   

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   b) What do y understand abt the molecular docking? 7
7. a) Define pro-drug and advantages associated with pro-drug formation. 8
   b) Explain abt HTS and its importance. 7
8. a) What is the role of nucleic acid-and protein micro array in target discovery and validation. 10
   b) Write a note on economy of drug discovery.

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