Download OU M.Pharma Pharmacology 2nd Sem 2018 1215PCI Principles Of Drug Discovery Question Paper

Download OU (Osmania University) M.Pharma-Pharmacology (Master of Pharmacy) 2nd Semester 2018 1215PCI Principles Of Drug Discovery Previous Question Paper

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CODE:1215/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II?Semester (PCI) Main Examination,
August 2018
Subject : Principles of Drug Discovery
Time : 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1. Explain Target and lead with examples. Write abt varis methods of target
identification 15
2. (a) Explain rational approach for drug design. (8)
(b) Explain in brief the role of proteomics in target identification. (7)
3. What is QSAR? Give advantages and disadvantages of QSAR. Explain Hantzsch
analysis and Free Wilson analysis. (15)
4. (a) Write a note on CoMFA. (7)
(b) How computer aided drug design is useful in new drug discovery and
development. (8)
5. (a) Describe the methods of lead optimization. (8)
(b) What do y understand abt De Novo drug design? (7)
6. (a) Write a note on prediction of protein structure. (8)
(b) Describe varis lead seeking methods in drug design. (7)
7. Write a note on
(a) Drug likeness screening (8)
(b) pharmacophore based screening (7)
8. (a) Write a principle involved in design of pro-drug. (8)
(b) Explain the term molecular docking. (7)
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