UNIVERSITY OF JAFFNA, SRI LANKA
FACULTY OF MEDICINE
FIRST EXAMINATION FOR MEDICAL DEGREES (2ND) - JUNE 2021
BIOCHEMISTRY PAPER II
(NEW CURRICULUM)
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15.06.2021 Time: 3 Hours
Answer all 10 questions.
Marks allotted to each part are indicated in brackets.
Answer Each Question on Separate Answer Book.
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- 1 Explain diabetes mellitus
- 1.1 Type I. (20 Marks)
- 1.2 Type II. (20 Marks)
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- 2 Give the fasting blood glucose levels to confirm that a person is diabetic or pre-diabetic. (10 Marks)
- 3 Name the test that is carried out to confirm gestational diabetes and explain how a pregnant woman can be prepared for the above mentioned test. (30 Marks)
- 4 Explain how the glycosylated haemoglobin (HbA1c) level is useful to consider the status of diabetes. (20 Marks)
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- 1 Explain diabetes mellitus
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- 1 Diagrammatically show the formation and catabolism of VLDL. (35 Marks)
- 2 Explain how cholesterol is catabolised. (25 Marks)
- 3 Explain the mechanism of actions of
- 3.1 Sulphonylurea (25 Marks)
- 3.2 Statin (15 Marks)
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- 1 Explain the basic principles of the actions of different goitrogenic factors. (25 Marks)
- 2 Give examples for goitrogenic factors. (20 Marks)
- 3 Explain how the thyroid hormone is released from the thyroid gland and transported in the blood. (15 Marks)
- 4 How the active form of thyroid hormone is formed in peripheral tissues? (15 Marks)
- 5 List the iodine deficiency disorders in adults, adolescents, children and neonates. (25 Marks)
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- 1 Explain the biochemical basis of
- 1.1 developing coma due to elevated blood ammonia level.
- 1.2 homocystinuria Type I. (50 Marks)
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- 2 Explain how the cyanide poisoning is affecting the biochemical reactions. (20 Marks) (30 Marks)
- 1 Explain the biochemical basis of
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- 1 The total serum bilirubin level of a 45 year old male was 4mg / 100 ml blood and the urine contained bilirubin with decreased urobilinogen.
- 1.1 What could be the probable diagnosis? (05 Marks)
- 1.2 Which fraction of the serum bilirubin is elevated in this patient? (05 Marks)
- 1.3 List the probable causes for the elevation in the above said fraction of bilirubin in the above patient. (15 Marks)
- 1.4 Explain the biochemical basis for the elevation of the fraction of bilirubin said in Section 5.1.2 under the conditions mentioned in Section 5.1.3. (25 Marks)
- 1.5 What further test would you perform with blood to confirm your diagnosis? Give the principle of the test. (20 Marks)
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- 2 Write short notes on cyclooxygenase -1 and Cyclooxygenase-2 inhibitors. (30 Marks)
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- 1 The total serum bilirubin level of a 45 year old male was 4mg / 100 ml blood and the urine contained bilirubin with decreased urobilinogen.
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- 1 Give the biochemical basis of the followings.
- 1.1 Consuming cold water fish oil is better than consuming butter. (25 Marks)
- 1.2 Amphipathic substances act as detergents. (20 Marks)
- 2 Give the serum electrophoretic pattern of a nephrotic syndrome patient comparing with that of a normal person. Explain the differences. (30 Marks)
- 3 The application of the isoenzymes of creative kinase for differential diagnosis of diseases. (25 Marks)
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- 1 Give the biochemical basis of the followings.
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- 1 Explain the role of bile in the digestion and absorption of fat. (20 Marks)
- 2 Give the functions of glycosaminoglycans? (15 Marks)
- 3 Diagrammatically show the glucose reabsorption mechanisms in kidney. (15 Marks)
- 4 Show how antibodies and memory cells are formed during immune response against an infection. (50 Marks)
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- 1 "More than 50% of the human cancers are associated with mutations in p53 gene" Explain. (30 Marks)
- 2 Explain with a diagram, how iron is absorbed into the intestinal epithelial cells ad stored. (30 Marks)
- 3 Glucose 6 phosphatase deficiency can lead to hyperuricemia. Explain. (40 Marks)
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- 1 Discuss the basis of developing microcytic and macrocytic anaemia after partial gastrectomy. (50 Marks)
- 2 Explain the biochemical functions of the following:
- 2.1 Vitamin K. (25 Marks)
- 2.2 Thiamine. (25 Marks)
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10. A male security guard of 40year old is having 65kg body weight and 1.8m height.
- 1 Calculate the Basic Metabolic Rate (BMR) of the Security Guard. (25 Marks)
- 2 What is his physical activity level? Explain. (10 Marks)
- 3 Calculate his Total Energy Expenditure (TEE) per day. (15 Marks)
- 4 To maintain zero energy balance by the above male security guard,
- 4.1 What proportion of energy should be obtained from carbohydrates, proteins and lipids? (15 Marks)
- 4.2 Give a day's menu to obtain the above nutrients considering the 'Healthy eating plate concept'. (35 Marks)
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